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Binding between Crossveinless-2 and Chordin Von Willebrand Factor Type C Domains Promotes BMP Signaling by Blocking Chordin Activity

BACKGROUND: Crossveinless-2 (CV2) is an extracellular BMP modulator protein of the Chordin family, which can either enhance or inhibit BMP activity. CV2 binds to BMP2 via subdomain 1 of the first of its five N-terminal von Willebrand factor type C domains (VWC1). Previous studies showed that this BM...

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Detalles Bibliográficos
Autores principales:	Zhang, Jin-Li, Patterson, Lucy J., Qiu, Li-Yan, Graziussi, Daria, Sebald, Walter, Hammerschmidt, Matthias
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944808/ https://www.ncbi.nlm.nih.gov/pubmed/20886103 http://dx.doi.org/10.1371/journal.pone.0012846

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