Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

AKT1 (NP_005154.2) is a member of the serine/threonine AGC protein kinase family involved in cellular metabolism, growth, proliferation and survival. The three human AKT isozymes are highly homologous multi-domain proteins with both overlapping and distinct cellular functions. Dysregulation of the A...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Wen-I, Voegtli, Walter C., Sturgis, Hillary L., Dizon, Faith P., Vigers, Guy P. A., Brandhuber, Barbara J.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944833/
https://www.ncbi.nlm.nih.gov/pubmed/20886116
http://dx.doi.org/10.1371/journal.pone.0012913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944833/
https://www.ncbi.nlm.nih.gov/pubmed/20886116
http://dx.doi.org/10.1371/journal.pone.0012913

Ejemplares similares