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Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

AKT1 (NP_005154.2) is a member of the serine/threonine AGC protein kinase family involved in cellular metabolism, growth, proliferation and survival. The three human AKT isozymes are highly homologous multi-domain proteins with both overlapping and distinct cellular functions. Dysregulation of the A...

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Detalles Bibliográficos
Autores principales:	Wu, Wen-I, Voegtli, Walter C., Sturgis, Hillary L., Dizon, Faith P., Vigers, Guy P. A., Brandhuber, Barbara J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944833/ https://www.ncbi.nlm.nih.gov/pubmed/20886116 http://dx.doi.org/10.1371/journal.pone.0012913

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