β2-Syntrophin Is a Cdk5 Substrate That Restrains the Motility of Insulin Secretory Granules

The molecular basis for the interaction of insulin granules with the cortical cytoskeleton of pancreatic β-cells remains unknown. We have proposed that binding of the granule protein ICA512 to the PDZ domain of β2-syntrophin anchors granules to actin filaments and that the phosphorylation/dephosphor...

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Detalles Bibliográficos
Autores principales: Schubert, Sandra, Knoch, Klaus-Peter, Ouwendijk, Joke, Mohammed, Shabaz, Bodrov, Yury, Jäger, Melanie, Altkrüger, Anke, Wegbrod, Carolin, Adams, Marvin E., Kim, Yong, Froehner, Stanley C., Jensen, Ole N., Kalaidzidis, Yannis, Solimena, Michele
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944849/
https://www.ncbi.nlm.nih.gov/pubmed/20886068
http://dx.doi.org/10.1371/journal.pone.0012929

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