Nondenaturing Purification of Co-Transcriptionally Folded RNA Avoids Common Folding Heterogeneity

Due to the energetic frustration of RNA folding, tertiary structured RNA is typically characterized by a rugged folding free energy landscape where deep kinetic barriers separate numerous misfolded states from one or more native states. While most in vitro studies of RNA rely on (re)folding chemical...

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Detalles Bibliográficos
Autores principales: Pereira, Miguel J. B., Behera, Vivek, Walter, Nils G.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944885/
https://www.ncbi.nlm.nih.gov/pubmed/20886091
http://dx.doi.org/10.1371/journal.pone.0012953

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