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Relationships of dietary patterns with body composition in older adults differ by gender and PPAR-γ Pro12Ala genotype

PURPOSE: Dietary patterns may better capture the multifaceted effects of diet on body composition than individual nutrients or foods. The objective of this study was to investigate the dietary patterns of a cohort of older adults, and examine relationships of dietary patterns with body composition....

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Autores principales: Anderson, Amy L., Harris, Tamara B., Houston, Denise K., Tylavsky, Frances A., Lee, Jung Sun, Sellmeyer, Deborah E., Sahyoun, Nadine R.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944967/
https://www.ncbi.nlm.nih.gov/pubmed/20174813
http://dx.doi.org/10.1007/s00394-010-0096-9
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author Anderson, Amy L.
Harris, Tamara B.
Houston, Denise K.
Tylavsky, Frances A.
Lee, Jung Sun
Sellmeyer, Deborah E.
Sahyoun, Nadine R.
author_facet Anderson, Amy L.
Harris, Tamara B.
Houston, Denise K.
Tylavsky, Frances A.
Lee, Jung Sun
Sellmeyer, Deborah E.
Sahyoun, Nadine R.
author_sort Anderson, Amy L.
collection PubMed
description PURPOSE: Dietary patterns may better capture the multifaceted effects of diet on body composition than individual nutrients or foods. The objective of this study was to investigate the dietary patterns of a cohort of older adults, and examine relationships of dietary patterns with body composition. The influence of a polymorphism in the peroxisome proliferator-activated receptor-γ (PPAR-γ) gene was considered. METHODS: The Health, Aging and Body Composition (Health ABC) Study is a prospective cohort study of 3,075 older adults. Participants’ body composition and genetic variation were measured in detail. Food intake was assessed with a semi-quantitative food frequency questionnaire (Block Dietary Data Systems, Berkeley, CA), and dietary patterns of 1,809 participants with complete data were derived by cluster analysis. RESULTS: Six clusters were identified, including a ‘Healthy foods’ cluster characterized by higher intake of low-fat dairy products, fruit, whole grains, poultry, fish and vegetables. An interaction was found between dietary patterns and PPAR-γ Pro12Ala genotype in relation to body composition. While Pro/Pro homozygous men and women in the ‘Healthy foods’ cluster did not differ significantly in body composition from those in other clusters, men with the Ala allele in the ‘Healthy foods’ cluster had significantly lower levels of adiposity than those in other clusters. Women with the Ala allele in the ‘Healthy foods’ cluster differed only in right thigh intermuscular fat from those in other clusters. CONCLUSIONS: Relationships between diet and body composition in older adults may differ by gender and by genetic factors such as PPAR-γ Pro12Ala genotype.
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spelling pubmed-29449672010-10-12 Relationships of dietary patterns with body composition in older adults differ by gender and PPAR-γ Pro12Ala genotype Anderson, Amy L. Harris, Tamara B. Houston, Denise K. Tylavsky, Frances A. Lee, Jung Sun Sellmeyer, Deborah E. Sahyoun, Nadine R. Eur J Nutr Original Contribution PURPOSE: Dietary patterns may better capture the multifaceted effects of diet on body composition than individual nutrients or foods. The objective of this study was to investigate the dietary patterns of a cohort of older adults, and examine relationships of dietary patterns with body composition. The influence of a polymorphism in the peroxisome proliferator-activated receptor-γ (PPAR-γ) gene was considered. METHODS: The Health, Aging and Body Composition (Health ABC) Study is a prospective cohort study of 3,075 older adults. Participants’ body composition and genetic variation were measured in detail. Food intake was assessed with a semi-quantitative food frequency questionnaire (Block Dietary Data Systems, Berkeley, CA), and dietary patterns of 1,809 participants with complete data were derived by cluster analysis. RESULTS: Six clusters were identified, including a ‘Healthy foods’ cluster characterized by higher intake of low-fat dairy products, fruit, whole grains, poultry, fish and vegetables. An interaction was found between dietary patterns and PPAR-γ Pro12Ala genotype in relation to body composition. While Pro/Pro homozygous men and women in the ‘Healthy foods’ cluster did not differ significantly in body composition from those in other clusters, men with the Ala allele in the ‘Healthy foods’ cluster had significantly lower levels of adiposity than those in other clusters. Women with the Ala allele in the ‘Healthy foods’ cluster differed only in right thigh intermuscular fat from those in other clusters. CONCLUSIONS: Relationships between diet and body composition in older adults may differ by gender and by genetic factors such as PPAR-γ Pro12Ala genotype. Springer-Verlag 2010-02-21 2010 /pmc/articles/PMC2944967/ /pubmed/20174813 http://dx.doi.org/10.1007/s00394-010-0096-9 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Original Contribution
Anderson, Amy L.
Harris, Tamara B.
Houston, Denise K.
Tylavsky, Frances A.
Lee, Jung Sun
Sellmeyer, Deborah E.
Sahyoun, Nadine R.
Relationships of dietary patterns with body composition in older adults differ by gender and PPAR-γ Pro12Ala genotype
title Relationships of dietary patterns with body composition in older adults differ by gender and PPAR-γ Pro12Ala genotype
title_full Relationships of dietary patterns with body composition in older adults differ by gender and PPAR-γ Pro12Ala genotype
title_fullStr Relationships of dietary patterns with body composition in older adults differ by gender and PPAR-γ Pro12Ala genotype
title_full_unstemmed Relationships of dietary patterns with body composition in older adults differ by gender and PPAR-γ Pro12Ala genotype
title_short Relationships of dietary patterns with body composition in older adults differ by gender and PPAR-γ Pro12Ala genotype
title_sort relationships of dietary patterns with body composition in older adults differ by gender and ppar-γ pro12ala genotype
topic Original Contribution
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944967/
https://www.ncbi.nlm.nih.gov/pubmed/20174813
http://dx.doi.org/10.1007/s00394-010-0096-9
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