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Discovering Tumor Suppressor Genes Through Genome-Wide Copy Number Analysis
Classical tumor suppressor gene discovery has largely involved linkage analysis and loss-of-heterozygosity (LOH) screens, followed by detailed mapping of relatively large chromosomal regions. Subsequent efforts made use of genome-wide PCR-based methods to detect rare homozygous deletions. More recen...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Bentham Science Publishers Ltd
2010
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944996/ https://www.ncbi.nlm.nih.gov/pubmed/21286308 http://dx.doi.org/10.2174/138920210791616734 |