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DNA Instability at Chromosomal Fragile Sites in Cancer

Human chromosomal fragile sites are specific genomic regions which exhibit gaps or breaks on metaphase chromosomes following conditions of partial replication stress. Fragile sites often coincide with genes that are frequently rearranged or deleted in human cancers, with over half of cancer-specific...

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Detalles Bibliográficos
Autores principales:	Dillon, Laura W, Burrow, Allison A, Wang, Yuh-Hwa
Formato:	Texto
Lenguaje:	English
Publicado:	Bentham Science Publishers Ltd. 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2944998/ https://www.ncbi.nlm.nih.gov/pubmed/21286310 http://dx.doi.org/10.2174/138920210791616699

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