TAM receptor ligands in lupus: Protein S but not Gas6 levels reflect disease activity in systemic lupus erythematosus

INTRODUCTION: The TAM (tyro 3, axl, mer) kinases are key regulators of innate immunity and are important in the phagocytosis of apoptotic cells. Gas6 and protein S are ligands for these TAM kinases and bind to phosphatidyl serine residues exposed during apoptosis. In animal models, absence of TAM ki...

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Detalles Bibliográficos
Autores principales: Suh, Chang-Hee, Hilliard, Brendan, Li, Sophia, Merrill, Joan T, Cohen, Philip L
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945040/
https://www.ncbi.nlm.nih.gov/pubmed/20637106
http://dx.doi.org/10.1186/ar3088

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