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Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 Mouse Model of Huntington’s Disease: Exercise, Adenosine Receptors and Ampakines

In the R6/2 mouse model of Huntington’s disease (HD) we examined the effects of a number of behavioral and pharmacological manipulations aimed at rescuing the progressive loss of synaptic communication between cerebral cortex and striatum. Two cohorts of transgenic mice with ~110 and 210 CAG repeats...

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Detalles Bibliográficos
Autores principales:	Cepeda, Carlos, Cummings, Damian M., Hickey, Miriam A., Kleiman-Weiner, Max, Chen, Jane Y., Watson, Joseph B., Levine, Michael S.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Huntington Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945295/ https://www.ncbi.nlm.nih.gov/pubmed/20877458 http://dx.doi.org/10.1371/currents.RRN1182

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