Experimental Generation of SNP Haplotype Signatures in Patients with Sickle Cell Anaemia

BACKGROUND: Sickle cell anemia is caused by a single type of mutation, a homozygous A→T substitution in the ß globin gene. Clinical severity is diverse, partially due to additional, disease-modifying genetic factors. We are studying one such modifier locus, HMIP (HBS1L-MYB intergenic polymorphism, c...

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Detalles Bibliográficos
Autores principales: Menzel, Stephan, Qin, Jian, Vasavda, Nisha, Thein, Swee Lay, Ramakrishnan, Ramesh
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945316/
https://www.ncbi.nlm.nih.gov/pubmed/20886046
http://dx.doi.org/10.1371/journal.pone.0013004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945316/
https://www.ncbi.nlm.nih.gov/pubmed/20886046
http://dx.doi.org/10.1371/journal.pone.0013004

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