Cargando…

Mild reductions in cytosolic NADP-dependent isocitrate dehydrogenase activity result in lower amino acid contents and pigmentation without impacting growth

Transgenic tomato (Solanum lycopersicum) plants were generated targeting the cytosolic NADP-dependent isocitrate dehydrogenase gene (SlICDH1) via the RNA interference approach. The resultant transformants displayed a relatively mild reduction in the expression and activity of the target enzyme in th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sulpice, Ronan, Sienkiewicz-Porzucek, Agata, Osorio, Sonia, Krahnert, Ina, Stitt, Mark, Fernie, Alisdair R., Nunes-Nesi, Adriano
Formato:	Texto
Lenguaje:	English
Publicado:	Springer Vienna 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945463/ https://www.ncbi.nlm.nih.gov/pubmed/20473773 http://dx.doi.org/10.1007/s00726-010-0617-0

Ejemplares similares

Mild Reductions in Mitochondrial NAD-Dependent Isocitrate Dehydrogenase Activity Result in Altered Nitrate Assimilation and Pigmentation But Do Not Impact Growth
por: Sienkiewicz-Porzucek, Agata, et al.
Publicado: (2010)

Enhancement of UVB radiation-mediated apoptosis by knockdown of cytosolic NADP(+)-dependent isocitrate dehydrogenase in HaCaT cells
por: Lee, Su Jeong, et al.
Publicado: (2014)

NADP(+)-dependent cytosolic isocitrate dehydrogenase provides NADPH in the presence of cadmium due to the moderate chelating effect of glutathione
por: Cho, Hyo Je, et al.
Publicado: (2018)

Functional relevance of dynamic properties of Dimeric NADP-dependent Isocitrate Dehydrogenases
por: Vinekar, Rithvik, et al.
Publicado: (2012)

Isocitrate protects DJ-1 null dopaminergic cells from oxidative stress through NADP(+)-dependent isocitrate dehydrogenase (IDH)
por: Yang, Jinsung, et al.
Publicado: (2017)

Multiple strategies to prevent oxidative stress in Arabidopsis plants lacking the malate valve enzyme NADP-malate dehydrogenase
por: Hebbelmann, Inga, et al.
Publicado: (2012)

Purification and Characterization of Cytoplasmic NADP(+)-Isocitrate Dehydrogenase, and Amplification of the Nadp(+)-IDH Gene from the Wing-Dimorphic Sand Field Cricket, Gryllus firmus
por: Zera, Anthony J., et al.
Publicado: (2011)

Genetic Analysis of Central Carbon Metabolism Unveils an Amino Acid Substitution That Alters Maize NAD-Dependent Isocitrate Dehydrogenase Activity
por: Zhang, Nengyi, et al.
Publicado: (2010)

Cytosolic Isocitrate Dehydrogenase from Arabidopsis thaliana Is Regulated by Glutathionylation
por: Niazi, Adnan Khan, et al.
Publicado: (2019)

Deficiency of a peroxisomal NADP-isocitrate dehydrogenase leads to dwarf plant and defect seed in upland cotton
por: Cao, Yuefen, et al.
Publicado: (2022)

2-Hydroxyglutarate Production, but Not Dominant Negative Function, Is Conferred by Glioma-Derived NADP(+)-Dependent Isocitrate Dehydrogenase Mutations
por: Jin, Genglin, et al.
Publicado: (2011)

Liposomes modified with cardiolipin can act as a platform to regulate the potential flux of NADP(+)-dependent isocitrate dehydrogenase
por: Suga, Keishi, et al.
Publicado: (2015)

Mitochondrial NADP(+)-dependent isocitrate dehydrogenase deficiency increases cisplatin-induced oxidative damage in the kidney tubule cells
por: Kong, Min Jung, et al.
Publicado: (2018)

Crystal Structures of the Putative Isocitrate Dehydrogenase from Sulfolobus tokodaii Strain 7 in the Apo and NADP(+)-Bound Forms
por: Kondo, Hisanori, et al.
Publicado: (2018)

Characterization of NAD(+)/NADP(+)-Specific Isocitrate Dehydrogenases From Oleaginous Fungus Mortierella alpina Involved in Lipid Accumulation
por: Tang, Xin, et al.
Publicado: (2021)

Biochemical and Phylogenetic Characterization of a Novel NADP(+)-Specific Isocitrate Dehydrogenase From the Marine Microalga Phaeodactylum tricornutum
por: Huang, Shiping, et al.
Publicado: (2021)

Pyrophosphate levels strongly influence ascorbate and starch content in tomato fruit
por: Osorio, Sonia, et al.
Publicado: (2013)

SIRT3 and GCN5L regulation of NADP+- and NADPH-driven reactions of mitochondrial isocitrate dehydrogenase IDH2
por: Smolková, Katarína, et al.
Publicado: (2020)

Determination of the Cytosolic NADPH/NADP Ratio in Saccharomyces cerevisiae using Shikimate Dehydrogenase as Sensor Reaction
por: Zhang, Jinrui, et al.
Publicado: (2015)

NADP-Dependent Isocitrate Dehydrogenase from Arabidopsis Roots Contributes in the Mechanism of Defence against the Nitro-Oxidative Stress Induced by Salinity
por: Leterrier, Marina, et al.
Publicado: (2012)

Phosphonate Analogs of 2-Oxoglutarate Perturb Metabolism and Gene Expression in Illuminated Arabidopsis Leaves
por: Araújo, Wagner L., et al.
Publicado: (2012)

The Central Carbon and Energy Metabolism of Marine Diatoms
por: Obata, Toshihiro, et al.
Publicado: (2013)

Characterization of In Vivo Function(s) of Members of the Plant Mitochondrial Carrier Family
por: Nunes-Nesi, Adriano, et al.
Publicado: (2020)

Metabolic Roles of Plant Mitochondrial Carriers
por: Fernie, Alisdair R., et al.
Publicado: (2020)

Gas-Chromatography Mass-Spectrometry (GC-MS) Based Metabolite Profiling Reveals Mannitol as a Major Storage Carbohydrate in the Coccolithophorid Alga Emiliania huxleyi.
por: Obata, Toshihiro, et al.
Publicado: (2013)

Isocitrate dehydrogenase mutations in myeloid malignancies
por: Medeiros, B C, et al.
Publicado: (2017)

A Role for Cytosolic Isocitrate Dehydrogenase as a Negative Regulator of Glucose Signaling for Insulin Secretion in Pancreatic ß-Cells
por: Guay, Claudiane, et al.
Publicado: (2013)

Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism
por: Su, Li, et al.
Publicado: (2020)

Isocitrate dehydrogenase inhibitors in acute myeloid leukemia
por: Liu, Xiaoyan, et al.
Publicado: (2019)

The Role of Isocitrate Dehydrogenases in Direct Reprogramming to Cardiomyocytes
por: Ishida, Tomoaki, et al.
Publicado: (2021)

In Vivo Selection for Formate Dehydrogenases with High Efficiency and Specificity toward NADP(+)
por: Calzadiaz-Ramirez, Liliana, et al.
Publicado: (2020)

Characterization of a recently evolved flavonol-phenylacyltransferase gene provides signatures of natural light selection in Brassicaceae
por: Tohge, Takayuki, et al.
Publicado: (2016)

Isocitrate dehydrogenase mutations: new opportunities for translational research
por: Keum, Young-Sam, et al.
Publicado: (2015)

Isocitrate dehydrogenases in physiology and cancer: biochemical and molecular insight
por: Al-Khallaf, Hamoud
Publicado: (2017)

Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics
por: Golub, Danielle, et al.
Publicado: (2019)

Ivosidenib in Isocitrate Dehydrogenase 1–Mutated Advanced Glioma
por: Mellinghoff, Ingo K., et al.
Publicado: (2020)

Wild-type isocitrate dehydrogenase under the spotlight in glioblastoma
por: Alzial, Gabriel, et al.
Publicado: (2021)

Isocitrate dehydrogenase gene variants in cancer and their clinical significance
por: Cadoux-Hudson, Thomas, et al.
Publicado: (2021)

Metabolic adaptations in cancers expressing isocitrate dehydrogenase mutations
por: Hvinden, Ingvild Comfort, et al.
Publicado: (2021)

The regulatory mechanisms and inhibitors of isocitrate dehydrogenase 1 in cancer
por: Liu, Yang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_lmtp9qtodj2pvvfl1r6prtbvn2