Effects of Olopatadine Hydrochloride, a Histamine H(1) Receptor Antagonist, on Histamine-Induced Skin Responses

Effects of olopatadine hydrochloride, a histamine H(1) receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate. Olopatadine significantly suppressed histamine-induced wheal, flare,...

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Detalles Bibliográficos
Autores principales: Hashimoto, Takashi, Ishii, Norito, Hamada, Takahiro, Dainichi, Teruki, Karashima, Tadashi, Nakama, Takekuni, Yasumoto, Shinichiro
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945667/
https://www.ncbi.nlm.nih.gov/pubmed/20886023
http://dx.doi.org/10.1155/2010/638051
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author Hashimoto, Takashi
Ishii, Norito
Hamada, Takahiro
Dainichi, Teruki
Karashima, Tadashi
Nakama, Takekuni
Yasumoto, Shinichiro
author_facet Hashimoto, Takashi
Ishii, Norito
Hamada, Takahiro
Dainichi, Teruki
Karashima, Tadashi
Nakama, Takekuni
Yasumoto, Shinichiro
author_sort Hashimoto, Takashi
collection PubMed
description Effects of olopatadine hydrochloride, a histamine H(1) receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate. Olopatadine significantly suppressed histamine-induced wheal, flare, and itch, starting 30 minutes after oral administration. Olopatadine was more effective than fexofenadine and bepotastine. None of the drugs studied impaired performance of word processing tasks. These results suggest that olopatadine can suppress skin symptoms caused by histamine soon after administration.
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spelling pubmed-29456672010-09-30 Effects of Olopatadine Hydrochloride, a Histamine H(1) Receptor Antagonist, on Histamine-Induced Skin Responses Hashimoto, Takashi Ishii, Norito Hamada, Takahiro Dainichi, Teruki Karashima, Tadashi Nakama, Takekuni Yasumoto, Shinichiro Dermatol Res Pract Research Article Effects of olopatadine hydrochloride, a histamine H(1) receptor antagonist, on histamine-induced skin responses were evaluated in 10 healthy subjects in comparison with placebo, fexofenadine hydrochloride, and bepotastine besilate. Olopatadine significantly suppressed histamine-induced wheal, flare, and itch, starting 30 minutes after oral administration. Olopatadine was more effective than fexofenadine and bepotastine. None of the drugs studied impaired performance of word processing tasks. These results suggest that olopatadine can suppress skin symptoms caused by histamine soon after administration. Hindawi Publishing Corporation 2010 2010-09-16 /pmc/articles/PMC2945667/ /pubmed/20886023 http://dx.doi.org/10.1155/2010/638051 Text en Copyright © 2010 Takashi Hashimoto et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Hashimoto, Takashi
Ishii, Norito
Hamada, Takahiro
Dainichi, Teruki
Karashima, Tadashi
Nakama, Takekuni
Yasumoto, Shinichiro
Effects of Olopatadine Hydrochloride, a Histamine H(1) Receptor Antagonist, on Histamine-Induced Skin Responses
title Effects of Olopatadine Hydrochloride, a Histamine H(1) Receptor Antagonist, on Histamine-Induced Skin Responses
title_full Effects of Olopatadine Hydrochloride, a Histamine H(1) Receptor Antagonist, on Histamine-Induced Skin Responses
title_fullStr Effects of Olopatadine Hydrochloride, a Histamine H(1) Receptor Antagonist, on Histamine-Induced Skin Responses
title_full_unstemmed Effects of Olopatadine Hydrochloride, a Histamine H(1) Receptor Antagonist, on Histamine-Induced Skin Responses
title_short Effects of Olopatadine Hydrochloride, a Histamine H(1) Receptor Antagonist, on Histamine-Induced Skin Responses
title_sort effects of olopatadine hydrochloride, a histamine h(1) receptor antagonist, on histamine-induced skin responses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945667/
https://www.ncbi.nlm.nih.gov/pubmed/20886023
http://dx.doi.org/10.1155/2010/638051
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