The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism

Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria. The function of TERT in mitochondria is largely unknown but the available findings point to a ro...

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Detalles Bibliográficos
Autores principales: Gordon, Donna M., Santos, Janine Hertzog
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945669/
https://www.ncbi.nlm.nih.gov/pubmed/20936168
http://dx.doi.org/10.4061/2010/390791
Descripción
Sumario:Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria. The function of TERT in mitochondria is largely unknown but the available findings point to a role in mitochondrial DNA metabolism. This paper discusses the available data on mitochondrial telomerase with particular emphasis on its effects upon the organellar DNA.

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