The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism

Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria. The function of TERT in mitochondria is largely unknown but the available findings point to a ro...

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Detalles Bibliográficos
Autores principales: Gordon, Donna M., Santos, Janine Hertzog
Formato: Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2010
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945669/
https://www.ncbi.nlm.nih.gov/pubmed/20936168
http://dx.doi.org/10.4061/2010/390791
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author Gordon, Donna M.
Santos, Janine Hertzog
author_facet Gordon, Donna M.
Santos, Janine Hertzog
author_sort Gordon, Donna M.
collection PubMed
description Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria. The function of TERT in mitochondria is largely unknown but the available findings point to a role in mitochondrial DNA metabolism. This paper discusses the available data on mitochondrial telomerase with particular emphasis on its effects upon the organellar DNA.
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spelling pubmed-29456692010-10-08 The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism Gordon, Donna M. Santos, Janine Hertzog J Nucleic Acids Review Article Telomerase is a reverse transcriptase specialized in telomere synthesis. The enzyme is primarily nuclear where it elongates telomeres but recent reports have shown that it also localizes to mitochondria. The function of TERT in mitochondria is largely unknown but the available findings point to a role in mitochondrial DNA metabolism. This paper discusses the available data on mitochondrial telomerase with particular emphasis on its effects upon the organellar DNA. SAGE-Hindawi Access to Research 2010-09-21 /pmc/articles/PMC2945669/ /pubmed/20936168 http://dx.doi.org/10.4061/2010/390791 Text en Copyright © 2010 D. M. Gordon and J. H. Santos. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Gordon, Donna M.
Santos, Janine Hertzog
The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism
title The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism
title_full The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism
title_fullStr The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism
title_full_unstemmed The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism
title_short The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism
title_sort emerging role of telomerase reverse transcriptase in mitochondrial dna metabolism
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945669/
https://www.ncbi.nlm.nih.gov/pubmed/20936168
http://dx.doi.org/10.4061/2010/390791
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