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Enhanced Susceptibility of Nasal Polyp Tissues to Avian and Human Influenza Viruses

BACKGROUND: Influenza viruses bind and infect respiratory epithelial cells through sialic acid on cell surface. Differential preference to sialic acid types contributes to host- and tissue-tropism of avian and seasonal influenza viruses. Although the highly pathogenic avian influenza virus H5N1 can...

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Autores principales: Suptawiwat, Ornpreya, Tantilipikorn, Pongsakorn, Boonarkart, Chompunuch, Lumyongsatien, Jate, Uiprasertkul, Mongkol, Puthavathana, Pilaipan, Auewarakul, Prasert
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945772/
https://www.ncbi.nlm.nih.gov/pubmed/20885984
http://dx.doi.org/10.1371/journal.pone.0012973
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author Suptawiwat, Ornpreya
Tantilipikorn, Pongsakorn
Boonarkart, Chompunuch
Lumyongsatien, Jate
Uiprasertkul, Mongkol
Puthavathana, Pilaipan
Auewarakul, Prasert
author_facet Suptawiwat, Ornpreya
Tantilipikorn, Pongsakorn
Boonarkart, Chompunuch
Lumyongsatien, Jate
Uiprasertkul, Mongkol
Puthavathana, Pilaipan
Auewarakul, Prasert
author_sort Suptawiwat, Ornpreya
collection PubMed
description BACKGROUND: Influenza viruses bind and infect respiratory epithelial cells through sialic acid on cell surface. Differential preference to sialic acid types contributes to host- and tissue-tropism of avian and seasonal influenza viruses. Although the highly pathogenic avian influenza virus H5N1 can infect and cause severe diseases in humans, it is not efficient in infecting human upper respiratory tract. This is because of the scarcity of its receptor, α2,3-linked sialic acid, in human upper airway. Expression of sialic acid can be influenced by various factors including inflammatory process. Allergic rhinitis and nasal polyp are common inflammatory conditions of nasal mucosa and may affect expression of the sialic acid and susceptibility to influenza infection. METHODOLOGY/PRINCIPAL FINDING: To test this hypothesis, we detected α2,3- and α2,6-linked sialic acid in human nasal polyp and normal nasal mucosal tissues by lectin staining and infected explants of those tissues with avian influenza viruses H5N1 and seasonal influenza viruses. We show here that mucosal surface of nasal polyp expressed higher level of α2,3- and α2,6-linked sialic acid than normal nasal mucosa. Accordingly, both H5N1 avian influenza viruses and seasonal influenza viruses replicated more efficiently in nasal polyp tissues explants. CONCLUSIONS/SIGNIFICANCE: Our data suggest a role of nasal inflammatory conditions in susceptibility to influenza infection, especially by avian influenza viruses, which is generally inefficient in infecting human upper airway. The increased receptor expression may contribute to increased susceptibility in some individuals. This may contribute to the gradual adaptation of the virus to human population.
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spelling pubmed-29457722010-09-30 Enhanced Susceptibility of Nasal Polyp Tissues to Avian and Human Influenza Viruses Suptawiwat, Ornpreya Tantilipikorn, Pongsakorn Boonarkart, Chompunuch Lumyongsatien, Jate Uiprasertkul, Mongkol Puthavathana, Pilaipan Auewarakul, Prasert PLoS One Research Article BACKGROUND: Influenza viruses bind and infect respiratory epithelial cells through sialic acid on cell surface. Differential preference to sialic acid types contributes to host- and tissue-tropism of avian and seasonal influenza viruses. Although the highly pathogenic avian influenza virus H5N1 can infect and cause severe diseases in humans, it is not efficient in infecting human upper respiratory tract. This is because of the scarcity of its receptor, α2,3-linked sialic acid, in human upper airway. Expression of sialic acid can be influenced by various factors including inflammatory process. Allergic rhinitis and nasal polyp are common inflammatory conditions of nasal mucosa and may affect expression of the sialic acid and susceptibility to influenza infection. METHODOLOGY/PRINCIPAL FINDING: To test this hypothesis, we detected α2,3- and α2,6-linked sialic acid in human nasal polyp and normal nasal mucosal tissues by lectin staining and infected explants of those tissues with avian influenza viruses H5N1 and seasonal influenza viruses. We show here that mucosal surface of nasal polyp expressed higher level of α2,3- and α2,6-linked sialic acid than normal nasal mucosa. Accordingly, both H5N1 avian influenza viruses and seasonal influenza viruses replicated more efficiently in nasal polyp tissues explants. CONCLUSIONS/SIGNIFICANCE: Our data suggest a role of nasal inflammatory conditions in susceptibility to influenza infection, especially by avian influenza viruses, which is generally inefficient in infecting human upper airway. The increased receptor expression may contribute to increased susceptibility in some individuals. This may contribute to the gradual adaptation of the virus to human population. Public Library of Science 2010-09-24 /pmc/articles/PMC2945772/ /pubmed/20885984 http://dx.doi.org/10.1371/journal.pone.0012973 Text en Suptawiwat et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Suptawiwat, Ornpreya
Tantilipikorn, Pongsakorn
Boonarkart, Chompunuch
Lumyongsatien, Jate
Uiprasertkul, Mongkol
Puthavathana, Pilaipan
Auewarakul, Prasert
Enhanced Susceptibility of Nasal Polyp Tissues to Avian and Human Influenza Viruses
title Enhanced Susceptibility of Nasal Polyp Tissues to Avian and Human Influenza Viruses
title_full Enhanced Susceptibility of Nasal Polyp Tissues to Avian and Human Influenza Viruses
title_fullStr Enhanced Susceptibility of Nasal Polyp Tissues to Avian and Human Influenza Viruses
title_full_unstemmed Enhanced Susceptibility of Nasal Polyp Tissues to Avian and Human Influenza Viruses
title_short Enhanced Susceptibility of Nasal Polyp Tissues to Avian and Human Influenza Viruses
title_sort enhanced susceptibility of nasal polyp tissues to avian and human influenza viruses
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2945772/
https://www.ncbi.nlm.nih.gov/pubmed/20885984
http://dx.doi.org/10.1371/journal.pone.0012973
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