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Gut inflammation provides a respiratory electron acceptor for Salmonella
Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in t...
Autores principales: | , , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946174/ https://www.ncbi.nlm.nih.gov/pubmed/20864996 http://dx.doi.org/10.1038/nature09415 |
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author | Winter, Sebastian E. Thiennimitr, Parameth Winter, Maria G. Butler, Brian P. Huseby, Douglas L. Crawford, Robert W. Russell, Joseph M. Bevins, Charles L. Adams, L. Garry Tsolis, Renée M. Roth, John R. Bäumler, Andreas J. |
author_facet | Winter, Sebastian E. Thiennimitr, Parameth Winter, Maria G. Butler, Brian P. Huseby, Douglas L. Crawford, Robert W. Russell, Joseph M. Bevins, Charles L. Adams, L. Garry Tsolis, Renée M. Roth, John R. Bäumler, Andreas J. |
author_sort | Winter, Sebastian E. |
collection | PubMed |
description | Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in the gut lumen through unknown mechanisms. Here we show that reactive oxygen species generated during inflammation reacted with endogenous, luminal sulphur compounds (thiosulfate) to form a new respiratory electron acceptor, tetrathionate. The genes conferring the ability to utilize tetrathionate as an electron acceptor produced a growth advantage for S. Typhimurium over the competing microbiota in the lumen of the inflamed gut. We conclude that S. Typhimurium virulence factors induce host-driven production of a new electron acceptor that allows the pathogen to use respiration to compete with fermenting gut microbes. Thus, the ability to trigger intestinal inflammation is crucial for the biology of this diarrhoeal pathogen. |
format | Text |
id | pubmed-2946174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
record_format | MEDLINE/PubMed |
spelling | pubmed-29461742011-03-23 Gut inflammation provides a respiratory electron acceptor for Salmonella Winter, Sebastian E. Thiennimitr, Parameth Winter, Maria G. Butler, Brian P. Huseby, Douglas L. Crawford, Robert W. Russell, Joseph M. Bevins, Charles L. Adams, L. Garry Tsolis, Renée M. Roth, John R. Bäumler, Andreas J. Nature Article Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in the gut lumen through unknown mechanisms. Here we show that reactive oxygen species generated during inflammation reacted with endogenous, luminal sulphur compounds (thiosulfate) to form a new respiratory electron acceptor, tetrathionate. The genes conferring the ability to utilize tetrathionate as an electron acceptor produced a growth advantage for S. Typhimurium over the competing microbiota in the lumen of the inflamed gut. We conclude that S. Typhimurium virulence factors induce host-driven production of a new electron acceptor that allows the pathogen to use respiration to compete with fermenting gut microbes. Thus, the ability to trigger intestinal inflammation is crucial for the biology of this diarrhoeal pathogen. 2010-09-23 /pmc/articles/PMC2946174/ /pubmed/20864996 http://dx.doi.org/10.1038/nature09415 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Winter, Sebastian E. Thiennimitr, Parameth Winter, Maria G. Butler, Brian P. Huseby, Douglas L. Crawford, Robert W. Russell, Joseph M. Bevins, Charles L. Adams, L. Garry Tsolis, Renée M. Roth, John R. Bäumler, Andreas J. Gut inflammation provides a respiratory electron acceptor for Salmonella |
title | Gut inflammation provides a respiratory electron acceptor for Salmonella |
title_full | Gut inflammation provides a respiratory electron acceptor for Salmonella |
title_fullStr | Gut inflammation provides a respiratory electron acceptor for Salmonella |
title_full_unstemmed | Gut inflammation provides a respiratory electron acceptor for Salmonella |
title_short | Gut inflammation provides a respiratory electron acceptor for Salmonella |
title_sort | gut inflammation provides a respiratory electron acceptor for salmonella |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946174/ https://www.ncbi.nlm.nih.gov/pubmed/20864996 http://dx.doi.org/10.1038/nature09415 |
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