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Gut inflammation provides a respiratory electron acceptor for Salmonella

Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in t...

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Autores principales: Winter, Sebastian E., Thiennimitr, Parameth, Winter, Maria G., Butler, Brian P., Huseby, Douglas L., Crawford, Robert W., Russell, Joseph M., Bevins, Charles L., Adams, L. Garry, Tsolis, Renée M., Roth, John R., Bäumler, Andreas J.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946174/
https://www.ncbi.nlm.nih.gov/pubmed/20864996
http://dx.doi.org/10.1038/nature09415
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author Winter, Sebastian E.
Thiennimitr, Parameth
Winter, Maria G.
Butler, Brian P.
Huseby, Douglas L.
Crawford, Robert W.
Russell, Joseph M.
Bevins, Charles L.
Adams, L. Garry
Tsolis, Renée M.
Roth, John R.
Bäumler, Andreas J.
author_facet Winter, Sebastian E.
Thiennimitr, Parameth
Winter, Maria G.
Butler, Brian P.
Huseby, Douglas L.
Crawford, Robert W.
Russell, Joseph M.
Bevins, Charles L.
Adams, L. Garry
Tsolis, Renée M.
Roth, John R.
Bäumler, Andreas J.
author_sort Winter, Sebastian E.
collection PubMed
description Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in the gut lumen through unknown mechanisms. Here we show that reactive oxygen species generated during inflammation reacted with endogenous, luminal sulphur compounds (thiosulfate) to form a new respiratory electron acceptor, tetrathionate. The genes conferring the ability to utilize tetrathionate as an electron acceptor produced a growth advantage for S. Typhimurium over the competing microbiota in the lumen of the inflamed gut. We conclude that S. Typhimurium virulence factors induce host-driven production of a new electron acceptor that allows the pathogen to use respiration to compete with fermenting gut microbes. Thus, the ability to trigger intestinal inflammation is crucial for the biology of this diarrhoeal pathogen.
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spelling pubmed-29461742011-03-23 Gut inflammation provides a respiratory electron acceptor for Salmonella Winter, Sebastian E. Thiennimitr, Parameth Winter, Maria G. Butler, Brian P. Huseby, Douglas L. Crawford, Robert W. Russell, Joseph M. Bevins, Charles L. Adams, L. Garry Tsolis, Renée M. Roth, John R. Bäumler, Andreas J. Nature Article Salmonella enterica serotype Typhimurium (S. Typhimurium) causes acute gut inflammation by using its virulence factors to invade the intestinal epithelium and survive in mucosal macrophages. The inflammatory response enhances the transmission success of S. Typhimurium by promoting its outgrowth in the gut lumen through unknown mechanisms. Here we show that reactive oxygen species generated during inflammation reacted with endogenous, luminal sulphur compounds (thiosulfate) to form a new respiratory electron acceptor, tetrathionate. The genes conferring the ability to utilize tetrathionate as an electron acceptor produced a growth advantage for S. Typhimurium over the competing microbiota in the lumen of the inflamed gut. We conclude that S. Typhimurium virulence factors induce host-driven production of a new electron acceptor that allows the pathogen to use respiration to compete with fermenting gut microbes. Thus, the ability to trigger intestinal inflammation is crucial for the biology of this diarrhoeal pathogen. 2010-09-23 /pmc/articles/PMC2946174/ /pubmed/20864996 http://dx.doi.org/10.1038/nature09415 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Winter, Sebastian E.
Thiennimitr, Parameth
Winter, Maria G.
Butler, Brian P.
Huseby, Douglas L.
Crawford, Robert W.
Russell, Joseph M.
Bevins, Charles L.
Adams, L. Garry
Tsolis, Renée M.
Roth, John R.
Bäumler, Andreas J.
Gut inflammation provides a respiratory electron acceptor for Salmonella
title Gut inflammation provides a respiratory electron acceptor for Salmonella
title_full Gut inflammation provides a respiratory electron acceptor for Salmonella
title_fullStr Gut inflammation provides a respiratory electron acceptor for Salmonella
title_full_unstemmed Gut inflammation provides a respiratory electron acceptor for Salmonella
title_short Gut inflammation provides a respiratory electron acceptor for Salmonella
title_sort gut inflammation provides a respiratory electron acceptor for salmonella
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946174/
https://www.ncbi.nlm.nih.gov/pubmed/20864996
http://dx.doi.org/10.1038/nature09415
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