Krüppel-like transcription factors and control of pluripotency

Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant. A paper by Parisi and colleagues in BMC Biolog...

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Detalles Bibliográficos
Autores principales: Bourillot, Pierre-Yves, Savatier, Pierre
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946285/
https://www.ncbi.nlm.nih.gov/pubmed/20875146
http://dx.doi.org/10.1186/1741-7007-8-125
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author Bourillot, Pierre-Yves
Savatier, Pierre
author_facet Bourillot, Pierre-Yves
Savatier, Pierre
author_sort Bourillot, Pierre-Yves
collection PubMed
description Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant. A paper by Parisi and colleagues in BMC Biology now sheds light on the mechanism by which Klf5 regulates pluripotency. See research article http://www.biomedcentral.com/1741-7007/8/128
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spelling pubmed-29462852010-09-28 Krüppel-like transcription factors and control of pluripotency Bourillot, Pierre-Yves Savatier, Pierre BMC Biol Commentary Recent papers have demonstrated a role for Krüppel-like transcription factors 2, 4 and 5 in the control of mouse embryonic stem cell pluripotency. However, it is not clear whether each factor has a unique role or whether they are functionally redundant. A paper by Parisi and colleagues in BMC Biology now sheds light on the mechanism by which Klf5 regulates pluripotency. See research article http://www.biomedcentral.com/1741-7007/8/128 BioMed Central 2010-09-27 /pmc/articles/PMC2946285/ /pubmed/20875146 http://dx.doi.org/10.1186/1741-7007-8-125 Text en Copyright ©2010 Bourillot and Savatier; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Bourillot, Pierre-Yves
Savatier, Pierre
Krüppel-like transcription factors and control of pluripotency
title Krüppel-like transcription factors and control of pluripotency
title_full Krüppel-like transcription factors and control of pluripotency
title_fullStr Krüppel-like transcription factors and control of pluripotency
title_full_unstemmed Krüppel-like transcription factors and control of pluripotency
title_short Krüppel-like transcription factors and control of pluripotency
title_sort krüppel-like transcription factors and control of pluripotency
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946285/
https://www.ncbi.nlm.nih.gov/pubmed/20875146
http://dx.doi.org/10.1186/1741-7007-8-125
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