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Factors Associated with the Acquisition and Severity of Gestational Listeriosis
Gravid mammals are more prone to listeriosis than their nongravid counterparts. However, many features of the disease in gravid animals are not well defined. We determined, in mice, that increased susceptibility to lethal infection following oral inoculation begins surprisingly early in pregnancy an...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946334/ https://www.ncbi.nlm.nih.gov/pubmed/20885996 http://dx.doi.org/10.1371/journal.pone.0013000 |
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author | Suyemoto, M. Mitsu Spears, Patricia A. Hamrick, Terri S. Barnes, Jill A. Havell, Edward A. Orndorff, Paul E. |
author_facet | Suyemoto, M. Mitsu Spears, Patricia A. Hamrick, Terri S. Barnes, Jill A. Havell, Edward A. Orndorff, Paul E. |
author_sort | Suyemoto, M. Mitsu |
collection | PubMed |
description | Gravid mammals are more prone to listeriosis than their nongravid counterparts. However, many features of the disease in gravid animals are not well defined. We determined, in mice, that increased susceptibility to lethal infection following oral inoculation begins surprisingly early in pregnancy and extends through embryonic development. Pregnancy did not demonstrably increase the spread of listeriae from the intestine to the liver and spleen in the initial 96 h period post inoculation. Consequently, it appeared that gravid animals were competent to contain an enteric infection, but in those instances where escape did occur, a lethal outcome was more likely. Interestingly, colonic colonization level and prevalence, measured 96 h post inoculation, was significantly higher in gravid individuals. In terms of human risk factors for listeriosis, our results suggest that the window of listeriosis susceptibility afforded by pregnancy may be open longer than previously appreciated. Our results also suggest that while gravid animals are competent to contain an enteric infection, enteric carriage rate may be more of a factor in defining disease incidence than previously considered. |
format | Text |
id | pubmed-2946334 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-29463342010-09-30 Factors Associated with the Acquisition and Severity of Gestational Listeriosis Suyemoto, M. Mitsu Spears, Patricia A. Hamrick, Terri S. Barnes, Jill A. Havell, Edward A. Orndorff, Paul E. PLoS One Research Article Gravid mammals are more prone to listeriosis than their nongravid counterparts. However, many features of the disease in gravid animals are not well defined. We determined, in mice, that increased susceptibility to lethal infection following oral inoculation begins surprisingly early in pregnancy and extends through embryonic development. Pregnancy did not demonstrably increase the spread of listeriae from the intestine to the liver and spleen in the initial 96 h period post inoculation. Consequently, it appeared that gravid animals were competent to contain an enteric infection, but in those instances where escape did occur, a lethal outcome was more likely. Interestingly, colonic colonization level and prevalence, measured 96 h post inoculation, was significantly higher in gravid individuals. In terms of human risk factors for listeriosis, our results suggest that the window of listeriosis susceptibility afforded by pregnancy may be open longer than previously appreciated. Our results also suggest that while gravid animals are competent to contain an enteric infection, enteric carriage rate may be more of a factor in defining disease incidence than previously considered. Public Library of Science 2010-09-27 /pmc/articles/PMC2946334/ /pubmed/20885996 http://dx.doi.org/10.1371/journal.pone.0013000 Text en Suyemoto et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Suyemoto, M. Mitsu Spears, Patricia A. Hamrick, Terri S. Barnes, Jill A. Havell, Edward A. Orndorff, Paul E. Factors Associated with the Acquisition and Severity of Gestational Listeriosis |
title | Factors Associated with the Acquisition and Severity of Gestational Listeriosis |
title_full | Factors Associated with the Acquisition and Severity of Gestational Listeriosis |
title_fullStr | Factors Associated with the Acquisition and Severity of Gestational Listeriosis |
title_full_unstemmed | Factors Associated with the Acquisition and Severity of Gestational Listeriosis |
title_short | Factors Associated with the Acquisition and Severity of Gestational Listeriosis |
title_sort | factors associated with the acquisition and severity of gestational listeriosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946334/ https://www.ncbi.nlm.nih.gov/pubmed/20885996 http://dx.doi.org/10.1371/journal.pone.0013000 |
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