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Factors Associated with the Acquisition and Severity of Gestational Listeriosis

Gravid mammals are more prone to listeriosis than their nongravid counterparts. However, many features of the disease in gravid animals are not well defined. We determined, in mice, that increased susceptibility to lethal infection following oral inoculation begins surprisingly early in pregnancy an...

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Autores principales: Suyemoto, M. Mitsu, Spears, Patricia A., Hamrick, Terri S., Barnes, Jill A., Havell, Edward A., Orndorff, Paul E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946334/
https://www.ncbi.nlm.nih.gov/pubmed/20885996
http://dx.doi.org/10.1371/journal.pone.0013000
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author Suyemoto, M. Mitsu
Spears, Patricia A.
Hamrick, Terri S.
Barnes, Jill A.
Havell, Edward A.
Orndorff, Paul E.
author_facet Suyemoto, M. Mitsu
Spears, Patricia A.
Hamrick, Terri S.
Barnes, Jill A.
Havell, Edward A.
Orndorff, Paul E.
author_sort Suyemoto, M. Mitsu
collection PubMed
description Gravid mammals are more prone to listeriosis than their nongravid counterparts. However, many features of the disease in gravid animals are not well defined. We determined, in mice, that increased susceptibility to lethal infection following oral inoculation begins surprisingly early in pregnancy and extends through embryonic development. Pregnancy did not demonstrably increase the spread of listeriae from the intestine to the liver and spleen in the initial 96 h period post inoculation. Consequently, it appeared that gravid animals were competent to contain an enteric infection, but in those instances where escape did occur, a lethal outcome was more likely. Interestingly, colonic colonization level and prevalence, measured 96 h post inoculation, was significantly higher in gravid individuals. In terms of human risk factors for listeriosis, our results suggest that the window of listeriosis susceptibility afforded by pregnancy may be open longer than previously appreciated. Our results also suggest that while gravid animals are competent to contain an enteric infection, enteric carriage rate may be more of a factor in defining disease incidence than previously considered.
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spelling pubmed-29463342010-09-30 Factors Associated with the Acquisition and Severity of Gestational Listeriosis Suyemoto, M. Mitsu Spears, Patricia A. Hamrick, Terri S. Barnes, Jill A. Havell, Edward A. Orndorff, Paul E. PLoS One Research Article Gravid mammals are more prone to listeriosis than their nongravid counterparts. However, many features of the disease in gravid animals are not well defined. We determined, in mice, that increased susceptibility to lethal infection following oral inoculation begins surprisingly early in pregnancy and extends through embryonic development. Pregnancy did not demonstrably increase the spread of listeriae from the intestine to the liver and spleen in the initial 96 h period post inoculation. Consequently, it appeared that gravid animals were competent to contain an enteric infection, but in those instances where escape did occur, a lethal outcome was more likely. Interestingly, colonic colonization level and prevalence, measured 96 h post inoculation, was significantly higher in gravid individuals. In terms of human risk factors for listeriosis, our results suggest that the window of listeriosis susceptibility afforded by pregnancy may be open longer than previously appreciated. Our results also suggest that while gravid animals are competent to contain an enteric infection, enteric carriage rate may be more of a factor in defining disease incidence than previously considered. Public Library of Science 2010-09-27 /pmc/articles/PMC2946334/ /pubmed/20885996 http://dx.doi.org/10.1371/journal.pone.0013000 Text en Suyemoto et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Suyemoto, M. Mitsu
Spears, Patricia A.
Hamrick, Terri S.
Barnes, Jill A.
Havell, Edward A.
Orndorff, Paul E.
Factors Associated with the Acquisition and Severity of Gestational Listeriosis
title Factors Associated with the Acquisition and Severity of Gestational Listeriosis
title_full Factors Associated with the Acquisition and Severity of Gestational Listeriosis
title_fullStr Factors Associated with the Acquisition and Severity of Gestational Listeriosis
title_full_unstemmed Factors Associated with the Acquisition and Severity of Gestational Listeriosis
title_short Factors Associated with the Acquisition and Severity of Gestational Listeriosis
title_sort factors associated with the acquisition and severity of gestational listeriosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946334/
https://www.ncbi.nlm.nih.gov/pubmed/20885996
http://dx.doi.org/10.1371/journal.pone.0013000
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