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Apoptosis Induction by MEK Inhibition in Human Lung Cancer Cells Is Mediated by Bim

AZD6244 (ARRY-142886) is an inhibitor of MEK1/2 and can inhibit cell proliferation or induce apoptosis in a cell-type dependent manner. The precise molecular mechanism of AZD6244-induced apoptosis is not clear. To investigate mechanisms of AZD6244 induced apoptosis in human lung cancer, we determine...

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Detalles Bibliográficos
Autores principales:	Meng, Jieru, Fang, Bingliang, Liao, Yong, Chresta, Christine M., Smith, Paul D., Roth, Jack A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946397/ https://www.ncbi.nlm.nih.gov/pubmed/20885957 http://dx.doi.org/10.1371/journal.pone.0013026

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