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Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men

Increased concentrations of circulating insulin-like growth factor-I (IGF-I) or IGF-I relative to IGF-binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a l...

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Autores principales: Nishida, Yuichiro, Matsubara, Takeshi, Tobina, Takuro, Shindo, Munehiro, Tokuyama, Kumpei, Tanaka, Keitaro, Tanaka, Hiroaki
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946576/
https://www.ncbi.nlm.nih.gov/pubmed/20885914
http://dx.doi.org/10.1155/2010/452820
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author Nishida, Yuichiro
Matsubara, Takeshi
Tobina, Takuro
Shindo, Munehiro
Tokuyama, Kumpei
Tanaka, Keitaro
Tanaka, Hiroaki
author_facet Nishida, Yuichiro
Matsubara, Takeshi
Tobina, Takuro
Shindo, Munehiro
Tokuyama, Kumpei
Tanaka, Keitaro
Tanaka, Hiroaki
author_sort Nishida, Yuichiro
collection PubMed
description Increased concentrations of circulating insulin-like growth factor-I (IGF-I) or IGF-I relative to IGF-binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a low-intensity exercise program on circulating levels of IGF-I, IGFBP-1, and IGFBP-3, in previously sedentary males. Fourteen healthy men participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/week for 6 weeks. After aerobic training, insulin sensitivity improved by 20%, while fasting insulin levels decreased by 13%. Simultaneously, low-intensity aerobic training decreased the circulating levels of IGF-I by 9%, while IGFBP-1 levels increased by 16%. An interesting finding was that higher pretraining level of IGF-I was associated with greater decline in IGF-I with training. Insulin-sensitizing low-intensity aerobic exercise is thus considered to be an effective method for downregulating IGF-I and upregulating IGFBP-1 levels.
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spelling pubmed-29465762010-09-30 Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men Nishida, Yuichiro Matsubara, Takeshi Tobina, Takuro Shindo, Munehiro Tokuyama, Kumpei Tanaka, Keitaro Tanaka, Hiroaki Int J Endocrinol Research Article Increased concentrations of circulating insulin-like growth factor-I (IGF-I) or IGF-I relative to IGF-binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk. This study aims to investigate the effect of a low-intensity exercise program on circulating levels of IGF-I, IGFBP-1, and IGFBP-3, in previously sedentary males. Fourteen healthy men participated in cycle ergometer training at lactate threshold intensity for 60 min/day, 5 days/week for 6 weeks. After aerobic training, insulin sensitivity improved by 20%, while fasting insulin levels decreased by 13%. Simultaneously, low-intensity aerobic training decreased the circulating levels of IGF-I by 9%, while IGFBP-1 levels increased by 16%. An interesting finding was that higher pretraining level of IGF-I was associated with greater decline in IGF-I with training. Insulin-sensitizing low-intensity aerobic exercise is thus considered to be an effective method for downregulating IGF-I and upregulating IGFBP-1 levels. Hindawi Publishing Corporation 2010 2010-09-22 /pmc/articles/PMC2946576/ /pubmed/20885914 http://dx.doi.org/10.1155/2010/452820 Text en Copyright © 2010 Yuichiro Nishida et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nishida, Yuichiro
Matsubara, Takeshi
Tobina, Takuro
Shindo, Munehiro
Tokuyama, Kumpei
Tanaka, Keitaro
Tanaka, Hiroaki
Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men
title Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men
title_full Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men
title_fullStr Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men
title_full_unstemmed Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men
title_short Effect of Low-Intensity Aerobic Exercise on Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-Binding Proteins in Healthy Men
title_sort effect of low-intensity aerobic exercise on insulin-like growth factor-i and insulin-like growth factor-binding proteins in healthy men
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946576/
https://www.ncbi.nlm.nih.gov/pubmed/20885914
http://dx.doi.org/10.1155/2010/452820
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