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Increased Plp1 gene expression leads to massive microglial cell activation and inflammation throughout the brain
PMD (Pelizaeus–Merzbacher disease) is a rare neurodegenerative disorder that impairs motor and cognitive functions and is associated with a shortened lifespan. The cause of PMD is mutations of the PLP1 [proteolipid protein 1 gene (human)] gene. Transgenic mice with increased Plp1 [proteolipid protei...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Neurochemistry
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946597/ https://www.ncbi.nlm.nih.gov/pubmed/20885931 http://dx.doi.org/10.1042/AN20100016 |