Cargando…

Parameters of Reserpine Analogs That Induce MSH2/MSH6-Dependent Cytotoxic Response

Mismatch repair proteins modulate the cytotoxicity of several chemotherapeutic agents. We have recently proposed a “death conformation” of the MutS homologous proteins that is distinguishable from their “repair conformation.” This conformation can be induced by a small molecule, reserpine, leading t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vasilyeva, Aksana, Clodfelter, Jill E., Gorczynski, Michael J., Gerardi, Anthony R., King, S. Bruce, Salsbury, Freddie, Scarpinato, Karin D.
Formato:	Texto
Lenguaje:	English
Publicado:	SAGE-Hindawi Access to Research 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946608/ https://www.ncbi.nlm.nih.gov/pubmed/20936178 http://dx.doi.org/10.4061/2010/162018

Ejemplares similares

Computational and synthetic studies towards improving rescinnamine as an inducer of MSH2-dependent apoptosis in cancer treatment
por: AbdelHafez, ElShimaa M. N., et al.
Publicado: (2013)

Cooperative Nuclear Localization Sequences Lend a Novel Role to the N-Terminal Region of MSH6
por: Gassman, Natalie R., et al.
Publicado: (2011)

MSH2 missense mutations alter cisplatin cytotoxicity and promote cisplatin-induced genome instability
por: Clodfelter, Jill E., et al.
Publicado: (2005)

The molecular mechanism of DNA damage recognition by MutS homologs and its consequences for cell death response
por: Salsbury, Freddie R., et al.
Publicado: (2006)

Somatic Hypermutation in Muts Homologue (Msh)3-, Msh6-, and Msh3/Msh6-Deficient Mice Reveals a Role for the Msh2–Msh6 Heterodimer in Modulating the Base Substitution Pattern
por: Wiesendanger, Margrit, et al.
Publicado: (2000)

Prerecognition Diffusion Mechanism of Human DNA Mismatch Repair Proteins along DNA: Msh2-Msh3 versus Msh2-Msh6
por: Pal, Arumay, et al.
Publicado: (2020)

Diffusion and Binding of Mismatch Repair Protein, MSH2, in Breast Cancer Cells at Different Stages of Neoplastic Transformation
por: Sigley, Justin, et al.
Publicado: (2017)

MSH6 syndrome
por: Suchy, Janina, et al.
Publicado: (2008)

The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers
por: Lawes, D A, et al.
Publicado: (2005)

A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch Recombination
por: Martomo, Stella A., et al.
Publicado: (2004)

Mismatch Recognition by Saccharomyces cerevisiae Msh2-Msh6: Role of Structure and Dynamics
por: Li, Yan, et al.
Publicado: (2019)

Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2–MSH6 complex
por: Banerjee, Sreeparna, et al.
Publicado: (2005)

Cadmium inhibits mismatch repair by blocking the ATPase activity of the MSH2–MSH6 complex
por: Banerjee, Sreeparna, et al.
Publicado: (2005)

Complex MSH2 and MSH6 mutations in hypermutated microsatellite unstable advanced prostate cancer
por: Pritchard, Colin C., et al.
Publicado: (2014)

Mlh1 interacts with both Msh2 and Msh6 for recruitment during mismatch repair
por: DuPrie, Matthew L., et al.
Publicado: (2022)

Crosstalk between MSH2–MSH3 and polβ promotes trinucleotide repeat expansion during base excision repair
por: Lai, Yanhao, et al.
Publicado: (2016)

Immunohistochemical Loss of the DNA Mismatch Repair Proteins MSH2 and MSH6 in Malignant Fibrous Histiocytomas
por: Ericson, Kajsa, et al.
Publicado: (2004)

Structural Insights into Saccharomyces cerevisiae Msh4–Msh5 Complex Function Using Homology Modeling
por: Rakshambikai, Ramaswamy, et al.
Publicado: (2013)

Msh4 and Msh5 Function in SC-Independent Chiasma Formation During the Streamlined Meiosis of Tetrahymena
por: Shodhan, Anura, et al.
Publicado: (2014)

MSH2 and MLH1 testing
por: Kurzawski, Grzegorz, et al.
Publicado: (2008)

UMD-MLH1/MSH2/MSH6 databases: description and analysis of genetic variations in French Lynch syndrome families
por: Grandval, Philippe, et al.
Publicado: (2013)

Characterization and comparative sequence analysis of the DNA mismatch repair MSH2 and MSH7 genes from tomato
por: Tam, Sheh May, et al.
Publicado: (2009)

MutS Homologues hMSH4 and hMSH5: Genetic Variations, Functions, and Implications in Human Diseases
por: Clark, Nicole, et al.
Publicado: (2013)

The Tendency of Having MSH2 and MSH6 Microsatellite Instability among Clinicopathological Features in Patients with Colorectal Cancer
por: Arshita, Neni, et al.
Publicado: (2018)

MSH2–MSH6 stimulates DNA polymerase η, suggesting a role for A:T mutations in antibody genes
por: Wilson, Teresa M., et al.
Publicado: (2005)

Genetic Analysis of Baker's Yeast Msh4-Msh5 Reveals a Threshold Crossover Level for Meiotic Viability
por: Nishant, K. T., et al.
Publicado: (2010)

Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients
por: Petersen, Sanne M, et al.
Publicado: (2013)

Prevalence and spectrum of MLH1, MSH2, and MSH6 pathogenic germline variants in Pakistani colorectal cancer patients
por: Rashid, Muhammad Usman, et al.
Publicado: (2019)

Modulation of host defense by the neuropeptide alpha-MSH.
por: Lipton, J. M.
Publicado: (1990)

Regulation of melanophore stimulating hormone (MSH) release.
por: Hadley, M. E., et al.
Publicado: (1973)

MSH-release inhibiting factors: recent studies.
por: Kastin, A. J., et al.
Publicado: (1973)

Thirty-five years of progress in the study of MSH.
por: Shizume, K.
Publicado: (1985)

Monad: introducing the MSH command shell and language
por: Oakley, Andy
Publicado: (2005)

Mutations in MSH5 in primary ovarian insufficiency
por: Guo, Ting, et al.
Publicado: (2017)

Loss or Somatic Mutations of hMSH2 Occur in Hereditary Nonpolyposis Colorectal Cancers with hMSH2 Germline Mutations
por: Lu, Shi‐Long, et al.
Publicado: (1996)

The properties of Msh2–Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair
por: Graham, William J., et al.
Publicado: (2018)

Desacetyl-α-MSH and α-MSH have sex specific interactions with diet to influence mouse gut morphology, metabolites and microbiota
por: Sun, Bo, et al.
Publicado: (2020)

Cytoplasmic MSH2 Related to Genomic Deletions in the MSH2/EPCAM Genes in Colorectal Cancer Patients With Suspected Lynch Syndrome
por: Dong, Lin, et al.
Publicado: (2021)

An Evaluation of the Immunohistochemical Expression of Mismatch Repair Proteins (MSH2, MSH6, MLH1, and PMS2) in Prostate Adenocarcinoma
por: Javeed, Saira, et al.
Publicado: (2022)

Novel α-MSH analog causes weight loss in obese rats and minipigs and improves insulin sensitivity
por: Fosgerau, Keld, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ro9fdbpit9tc3ofiufa33c99uv