Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma

The aim of this study was to investigate the expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma (HCC) and their clinicopathological significance. The expression of Tspan-1, Jab1 and p27 was detected in HCC tissues, the tissues around cancer (76 cases), and the normal tissues aroun...

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Autores principales: Chen, Li, Yuan, Daiyue, Wang, Gui-lan, Wang, You, Wu, Yuan-Yuan, Zhu, Jianwei
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946652/
https://www.ncbi.nlm.nih.gov/pubmed/20890423
http://dx.doi.org/10.3346/jkms.2010.25.10.1438
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author Chen, Li
Yuan, Daiyue
Wang, Gui-lan
Wang, You
Wu, Yuan-Yuan
Zhu, Jianwei
author_facet Chen, Li
Yuan, Daiyue
Wang, Gui-lan
Wang, You
Wu, Yuan-Yuan
Zhu, Jianwei
author_sort Chen, Li
collection PubMed
description The aim of this study was to investigate the expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma (HCC) and their clinicopathological significance. The expression of Tspan-1, Jab1 and p27 was detected in HCC tissues, the tissues around cancer (76 cases), and the normal tissues around the liver hemangiomas (10 cases). The overexpression of Tspan-1 and Jab1 was found in HCC tissues, positively correlated with clinical stage and negatively correlated with survival rate. The expression of p27 was found inversely linked to which of Tspan-1 and Jab1. In conclusion, the expression of Tspan-1, Jab1 and p27 is significantly associated with development of HCC. Overexpression of Tspan-1 and Jab1 suggests poor prognosis but overexpression of p27 may expect good prognosis for patients with HCC.
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spelling pubmed-29466522010-10-02 Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma Chen, Li Yuan, Daiyue Wang, Gui-lan Wang, You Wu, Yuan-Yuan Zhu, Jianwei J Korean Med Sci Original Article The aim of this study was to investigate the expression of Tspan-1, Jab1 and p27 in human hepatocellular carcinoma (HCC) and their clinicopathological significance. The expression of Tspan-1, Jab1 and p27 was detected in HCC tissues, the tissues around cancer (76 cases), and the normal tissues around the liver hemangiomas (10 cases). The overexpression of Tspan-1 and Jab1 was found in HCC tissues, positively correlated with clinical stage and negatively correlated with survival rate. The expression of p27 was found inversely linked to which of Tspan-1 and Jab1. In conclusion, the expression of Tspan-1, Jab1 and p27 is significantly associated with development of HCC. Overexpression of Tspan-1 and Jab1 suggests poor prognosis but overexpression of p27 may expect good prognosis for patients with HCC. The Korean Academy of Medical Sciences 2010-10 2010-09-17 /pmc/articles/PMC2946652/ /pubmed/20890423 http://dx.doi.org/10.3346/jkms.2010.25.10.1438 Text en © 2010 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Chen, Li
Yuan, Daiyue
Wang, Gui-lan
Wang, You
Wu, Yuan-Yuan
Zhu, Jianwei
Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma
title Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma
title_full Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma
title_fullStr Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma
title_full_unstemmed Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma
title_short Clinicopathological Significance of Expression of Tspan-1, Jab1 and p27 in Human Hepatocellular Carcinoma
title_sort clinicopathological significance of expression of tspan-1, jab1 and p27 in human hepatocellular carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946652/
https://www.ncbi.nlm.nih.gov/pubmed/20890423
http://dx.doi.org/10.3346/jkms.2010.25.10.1438
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