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Quinolone and Cephalosporin Resistance in Enteric Fever

Enteric fever is a major public health problem in developing countries. Ciprofloxacin resistance has now become a norm in the Indian subcontinent. Novel molecular substitutions may become frequent in future owing to selective pressures exerted by the irrational use of ciprofloxacin in human and vete...

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Detalles Bibliográficos
Autores principales: Capoor, Malini Rajinder, Nair, Deepthi
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946683/
https://www.ncbi.nlm.nih.gov/pubmed/20927288
http://dx.doi.org/10.4103/0974-777X.68529
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author Capoor, Malini Rajinder
Nair, Deepthi
author_facet Capoor, Malini Rajinder
Nair, Deepthi
author_sort Capoor, Malini Rajinder
collection PubMed
description Enteric fever is a major public health problem in developing countries. Ciprofloxacin resistance has now become a norm in the Indian subcontinent. Novel molecular substitutions may become frequent in future owing to selective pressures exerted by the irrational use of ciprofloxacin in human and veterinary therapeutics, in a population endemic with nalidixic acid-resistant strains. The therapeutics of ciprofloxacin-resistant enteric fever narrows down to third- and fourth-generation cephalosporins, azithromycin, tigecycline and penems. The first-line antimicrobials ampicillin, chloramphenicol and co-trimoxazole need to be rolled back. Antimicrobial surveillance coupled with molecular analysis of fluoroquinolone resistance is warranted for reconfirming novel and established molecular patterns for therapeutic reappraisal and for novel-drug targets. This review explores the antimicrobial resistance and its molecular mechanisms, as well as novel drugs in the therapy of enteric fever.
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spelling pubmed-29466832010-10-06 Quinolone and Cephalosporin Resistance in Enteric Fever Capoor, Malini Rajinder Nair, Deepthi J Glob Infect Dis Symposium on Infectious Agents in a Multidrug Resistant Globe Enteric fever is a major public health problem in developing countries. Ciprofloxacin resistance has now become a norm in the Indian subcontinent. Novel molecular substitutions may become frequent in future owing to selective pressures exerted by the irrational use of ciprofloxacin in human and veterinary therapeutics, in a population endemic with nalidixic acid-resistant strains. The therapeutics of ciprofloxacin-resistant enteric fever narrows down to third- and fourth-generation cephalosporins, azithromycin, tigecycline and penems. The first-line antimicrobials ampicillin, chloramphenicol and co-trimoxazole need to be rolled back. Antimicrobial surveillance coupled with molecular analysis of fluoroquinolone resistance is warranted for reconfirming novel and established molecular patterns for therapeutic reappraisal and for novel-drug targets. This review explores the antimicrobial resistance and its molecular mechanisms, as well as novel drugs in the therapy of enteric fever. Medknow Publications 2010 /pmc/articles/PMC2946683/ /pubmed/20927288 http://dx.doi.org/10.4103/0974-777X.68529 Text en © Journal of Global Infectious Diseases http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Symposium on Infectious Agents in a Multidrug Resistant Globe
Capoor, Malini Rajinder
Nair, Deepthi
Quinolone and Cephalosporin Resistance in Enteric Fever
title Quinolone and Cephalosporin Resistance in Enteric Fever
title_full Quinolone and Cephalosporin Resistance in Enteric Fever
title_fullStr Quinolone and Cephalosporin Resistance in Enteric Fever
title_full_unstemmed Quinolone and Cephalosporin Resistance in Enteric Fever
title_short Quinolone and Cephalosporin Resistance in Enteric Fever
title_sort quinolone and cephalosporin resistance in enteric fever
topic Symposium on Infectious Agents in a Multidrug Resistant Globe
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946683/
https://www.ncbi.nlm.nih.gov/pubmed/20927288
http://dx.doi.org/10.4103/0974-777X.68529
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AT nairdeepthi quinoloneandcephalosporinresistanceinentericfever