Immunomodulators for Asthma

New information regarding the molecular mechanisms of allergic disorders has led to a variety of novel therapeutic approaches. This article briefly reviews the pathogenesis of asthma and allergic diseases, discusses the rationale behind using immunomodulators in these diseases; and examines the ther...

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Detalles Bibliográficos
Autores principales: Dimov, Vesselin V, Casale, Thomas B
Formato: Texto
Lenguaje:English
Publicado: The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946700/
https://www.ncbi.nlm.nih.gov/pubmed/20885907
http://dx.doi.org/10.4168/aair.2010.2.4.228
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author Dimov, Vesselin V
Casale, Thomas B
author_facet Dimov, Vesselin V
Casale, Thomas B
author_sort Dimov, Vesselin V
collection PubMed
description New information regarding the molecular mechanisms of allergic disorders has led to a variety of novel therapeutic approaches. This article briefly reviews the pathogenesis of asthma and allergic diseases, discusses the rationale behind using immunomodulators in these diseases; and examines the therapeutic effects of immunomodulators on allergic diseases. There are a number of immunomodulators that have been developed for the treatment of allergic disorders. Some have looked very promising in pre-clinical trials, but have not shown significant benefits in human clinical trials thus indicating the disparity between mouse models and human asthma. This review focuses on immunomodulators that are in human clinical trials and not molecules in pre-clinical development.
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spelling pubmed-29467002010-10-01 Immunomodulators for Asthma Dimov, Vesselin V Casale, Thomas B Allergy Asthma Immunol Res Review New information regarding the molecular mechanisms of allergic disorders has led to a variety of novel therapeutic approaches. This article briefly reviews the pathogenesis of asthma and allergic diseases, discusses the rationale behind using immunomodulators in these diseases; and examines the therapeutic effects of immunomodulators on allergic diseases. There are a number of immunomodulators that have been developed for the treatment of allergic disorders. Some have looked very promising in pre-clinical trials, but have not shown significant benefits in human clinical trials thus indicating the disparity between mouse models and human asthma. This review focuses on immunomodulators that are in human clinical trials and not molecules in pre-clinical development. The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease 2010-10 2010-05-17 /pmc/articles/PMC2946700/ /pubmed/20885907 http://dx.doi.org/10.4168/aair.2010.2.4.228 Text en Copyright © 2010 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Dimov, Vesselin V
Casale, Thomas B
Immunomodulators for Asthma
title Immunomodulators for Asthma
title_full Immunomodulators for Asthma
title_fullStr Immunomodulators for Asthma
title_full_unstemmed Immunomodulators for Asthma
title_short Immunomodulators for Asthma
title_sort immunomodulators for asthma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946700/
https://www.ncbi.nlm.nih.gov/pubmed/20885907
http://dx.doi.org/10.4168/aair.2010.2.4.228
work_keys_str_mv AT dimovvesselinv immunomodulatorsforasthma
AT casalethomasb immunomodulatorsforasthma

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