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Evaluation of serum immunoglobulin E levels in bronchial asthma
BACKGROUND: Immunoglobulin E and associated cellular responses are responsible for allergic airway diseases. A hypersensitivity reaction initiated by immunologic mechanisms, mediated by IgE antibodies occurs in allergic asthma AIM: To estimate and compare serum IgE levels in mild, moderate, and seve...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946714/ https://www.ncbi.nlm.nih.gov/pubmed/20931031 http://dx.doi.org/10.4103/0970-2113.68312 |
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author | Sandeep, Thirunavukkarasu Roopakala, Mysore Subrahmanyam Silvia, Chickballapur Rayappa Wilma Delphine Chandrashekara, Srikantaiah Rao, Mohan |
author_facet | Sandeep, Thirunavukkarasu Roopakala, Mysore Subrahmanyam Silvia, Chickballapur Rayappa Wilma Delphine Chandrashekara, Srikantaiah Rao, Mohan |
author_sort | Sandeep, Thirunavukkarasu |
collection | PubMed |
description | BACKGROUND: Immunoglobulin E and associated cellular responses are responsible for allergic airway diseases. A hypersensitivity reaction initiated by immunologic mechanisms, mediated by IgE antibodies occurs in allergic asthma AIM: To estimate and compare serum IgE levels in mild, moderate, and severe asthmatics and in normal subjects and to obtain a mathematical model describing the relationship between serum IgE levels and severity of asthma. MATERIALS AND METHODS: A stratified sample of 60 patients within age group of 18-60 years and 31 male and 29 female asthmatic patients and 13 healthy controls within 18-60 years were included in this study and classified according to GINA classification. Serum IgE levels were estimated by using ELISA kit. RESULTS: Mean IgE levels ranged from 151.95 IU/ml in normal subjects to 1045.32 IU/ml in severe asthmatics. The model developed was 27% efficient. CONCLUSION: Serum Immunoglobulin E levels were high in asthmatics as compared to normal subjects. On an average, the levels increased as the severity of asthma increased. However, there was no statistically significant correlation since the variability in each level of asthma was very large |
format | Text |
id | pubmed-2946714 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-29467142010-10-07 Evaluation of serum immunoglobulin E levels in bronchial asthma Sandeep, Thirunavukkarasu Roopakala, Mysore Subrahmanyam Silvia, Chickballapur Rayappa Wilma Delphine Chandrashekara, Srikantaiah Rao, Mohan Lung India Original Article BACKGROUND: Immunoglobulin E and associated cellular responses are responsible for allergic airway diseases. A hypersensitivity reaction initiated by immunologic mechanisms, mediated by IgE antibodies occurs in allergic asthma AIM: To estimate and compare serum IgE levels in mild, moderate, and severe asthmatics and in normal subjects and to obtain a mathematical model describing the relationship between serum IgE levels and severity of asthma. MATERIALS AND METHODS: A stratified sample of 60 patients within age group of 18-60 years and 31 male and 29 female asthmatic patients and 13 healthy controls within 18-60 years were included in this study and classified according to GINA classification. Serum IgE levels were estimated by using ELISA kit. RESULTS: Mean IgE levels ranged from 151.95 IU/ml in normal subjects to 1045.32 IU/ml in severe asthmatics. The model developed was 27% efficient. CONCLUSION: Serum Immunoglobulin E levels were high in asthmatics as compared to normal subjects. On an average, the levels increased as the severity of asthma increased. However, there was no statistically significant correlation since the variability in each level of asthma was very large Medknow Publications 2010 /pmc/articles/PMC2946714/ /pubmed/20931031 http://dx.doi.org/10.4103/0970-2113.68312 Text en © Lung India http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sandeep, Thirunavukkarasu Roopakala, Mysore Subrahmanyam Silvia, Chickballapur Rayappa Wilma Delphine Chandrashekara, Srikantaiah Rao, Mohan Evaluation of serum immunoglobulin E levels in bronchial asthma |
title | Evaluation of serum immunoglobulin E levels in bronchial asthma |
title_full | Evaluation of serum immunoglobulin E levels in bronchial asthma |
title_fullStr | Evaluation of serum immunoglobulin E levels in bronchial asthma |
title_full_unstemmed | Evaluation of serum immunoglobulin E levels in bronchial asthma |
title_short | Evaluation of serum immunoglobulin E levels in bronchial asthma |
title_sort | evaluation of serum immunoglobulin e levels in bronchial asthma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946714/ https://www.ncbi.nlm.nih.gov/pubmed/20931031 http://dx.doi.org/10.4103/0970-2113.68312 |
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