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Liver Involvement Associated with Dengue Infection in Adults in Vietnam
Globally, the number of adults hospitalized with dengue has increased markedly in recent years. It has been suggested that hepatic dysfunction is more significant in this group than among children. We describe the spectrum and evolution of disease manifestations among 644 adults with dengue who were...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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The American Society of Tropical Medicine and Hygiene
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946741/ https://www.ncbi.nlm.nih.gov/pubmed/20889864 http://dx.doi.org/10.4269/ajtmh.2010.10-0090 |
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author | Trung, Dinh The Thao, Le Thi Thu Hien, Tran Tinh Hung, Nguyen The Vinh, Nguyen Ngoc Hien, Pham Tran Dieu Chinh, Nguyen Tran Simmons, Cameron Wills, Bridget |
author_facet | Trung, Dinh The Thao, Le Thi Thu Hien, Tran Tinh Hung, Nguyen The Vinh, Nguyen Ngoc Hien, Pham Tran Dieu Chinh, Nguyen Tran Simmons, Cameron Wills, Bridget |
author_sort | Trung, Dinh The |
collection | PubMed |
description | Globally, the number of adults hospitalized with dengue has increased markedly in recent years. It has been suggested that hepatic dysfunction is more significant in this group than among children. We describe the spectrum and evolution of disease manifestations among 644 adults with dengue who were prospectively recruited on admission to a major infectious disease hospital in southern Vietnam and compare them with a group of patients with similar illnesses not caused by dengue. Transaminase levels increased in virtually all dengue patients and correlated with other markers of disease severity. However, peak enzyme values usually occurred later than other complications. Clinically severe liver involvement was infrequent and idiosyncratic, but usually resulted in severe bleeding. Chronic co-infection with hepatitis B was associated with modestly but significantly increased levels of alanine aminotransferase, but did not otherwise impact the clinical picture. |
format | Text |
id | pubmed-2946741 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | The American Society of Tropical Medicine and Hygiene |
record_format | MEDLINE/PubMed |
spelling | pubmed-29467412010-10-06 Liver Involvement Associated with Dengue Infection in Adults in Vietnam Trung, Dinh The Thao, Le Thi Thu Hien, Tran Tinh Hung, Nguyen The Vinh, Nguyen Ngoc Hien, Pham Tran Dieu Chinh, Nguyen Tran Simmons, Cameron Wills, Bridget Am J Trop Med Hyg Articles Globally, the number of adults hospitalized with dengue has increased markedly in recent years. It has been suggested that hepatic dysfunction is more significant in this group than among children. We describe the spectrum and evolution of disease manifestations among 644 adults with dengue who were prospectively recruited on admission to a major infectious disease hospital in southern Vietnam and compare them with a group of patients with similar illnesses not caused by dengue. Transaminase levels increased in virtually all dengue patients and correlated with other markers of disease severity. However, peak enzyme values usually occurred later than other complications. Clinically severe liver involvement was infrequent and idiosyncratic, but usually resulted in severe bleeding. Chronic co-infection with hepatitis B was associated with modestly but significantly increased levels of alanine aminotransferase, but did not otherwise impact the clinical picture. The American Society of Tropical Medicine and Hygiene 2010-10-05 /pmc/articles/PMC2946741/ /pubmed/20889864 http://dx.doi.org/10.4269/ajtmh.2010.10-0090 Text en ©The American Society of Tropical Medicine and Hygiene http://creativecommons.org/licenses/by/2.5/ This is an Open Access article distributed under the terms of the American Society of Tropical Medicine and Hygiene's Re-use License which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Trung, Dinh The Thao, Le Thi Thu Hien, Tran Tinh Hung, Nguyen The Vinh, Nguyen Ngoc Hien, Pham Tran Dieu Chinh, Nguyen Tran Simmons, Cameron Wills, Bridget Liver Involvement Associated with Dengue Infection in Adults in Vietnam |
title | Liver Involvement Associated with Dengue Infection in Adults in Vietnam |
title_full | Liver Involvement Associated with Dengue Infection in Adults in Vietnam |
title_fullStr | Liver Involvement Associated with Dengue Infection in Adults in Vietnam |
title_full_unstemmed | Liver Involvement Associated with Dengue Infection in Adults in Vietnam |
title_short | Liver Involvement Associated with Dengue Infection in Adults in Vietnam |
title_sort | liver involvement associated with dengue infection in adults in vietnam |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946741/ https://www.ncbi.nlm.nih.gov/pubmed/20889864 http://dx.doi.org/10.4269/ajtmh.2010.10-0090 |
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