Mycobacterium africanum—Review of an Important Cause of Human Tuberculosis in West Africa

Mycobacterium africanum consists of two phylogenetically distinct lineages within the Mycobacterium tuberculosis complex, known as M. africanum West African 1 and M. africanum West African 2. These lineages are restricted to West Africa, where they cause up to half of human pulmonary tuberculosis. I...

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Detalles Bibliográficos
Autores principales: de Jong, Bouke C., Antonio, Martin, Gagneux, Sebastien
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946903/
https://www.ncbi.nlm.nih.gov/pubmed/20927191
http://dx.doi.org/10.1371/journal.pntd.0000744
Descripción
Sumario:Mycobacterium africanum consists of two phylogenetically distinct lineages within the Mycobacterium tuberculosis complex, known as M. africanum West African 1 and M. africanum West African 2. These lineages are restricted to West Africa, where they cause up to half of human pulmonary tuberculosis. In this review we discuss the definition of M. africanum, describe the prevalence and restricted geographical distribution of M. africanum West African 1 and 2, review the occurrence of M. africanum in animals, and summarize the phenotypic differences described thus far between M. africanum and M. tuberculosis sensu stricto.

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