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Relating Mutant Genotype to Phenotype via Quantitative Behavior of the NADPH Redox Cycle in Human Erythrocytes

BACKGROUND: The NADPH redox cycle plays a key role in antioxidant protection of human erythrocytes. It consists of two enzymes: glucose-6-phosphate dehydrogenase (G6PD) and glutathione reductase. Over 160 G6PD variants have been characterized and associated with several distinct clinical manifestati...

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Detalles Bibliográficos
Autores principales:	Coelho, Pedro M. B. M., Salvador, Armindo, Savageau, Michael A.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946920/ https://www.ncbi.nlm.nih.gov/pubmed/20927393 http://dx.doi.org/10.1371/journal.pone.0013031

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