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A Selection Fit Mechanism in BMP Receptor IA as a Possible Source for BMP Ligand-Receptor Promiscuity
BACKGROUND: Members of the TGF-β superfamily are characterized by a highly promiscuous ligand-receptor interaction as is readily apparent from the numeral discrepancy of only seven type I and five type II receptors available for more than 40 ligands. Structural and functional studies have been used...
Autores principales: | Harth, Stefan, Kotzsch, Alexander, Hu, Junli, Sebald, Walter, Mueller, Thomas D. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946932/ https://www.ncbi.nlm.nih.gov/pubmed/20927405 http://dx.doi.org/10.1371/journal.pone.0013049 |
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