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A Selection Fit Mechanism in BMP Receptor IA as a Possible Source for BMP Ligand-Receptor Promiscuity

BACKGROUND: Members of the TGF-β superfamily are characterized by a highly promiscuous ligand-receptor interaction as is readily apparent from the numeral discrepancy of only seven type I and five type II receptors available for more than 40 ligands. Structural and functional studies have been used...

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Detalles Bibliográficos
Autores principales: Harth, Stefan, Kotzsch, Alexander, Hu, Junli, Sebald, Walter, Mueller, Thomas D.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2946932/
https://www.ncbi.nlm.nih.gov/pubmed/20927405
http://dx.doi.org/10.1371/journal.pone.0013049

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