Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

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The immune response plays an important role in staving off cancer; however, mechanisms of immunosuppression hinder productive anti-tumor immunity. T cell dysfunction or exhaustion in tumor-bearing hosts is one such mechanism. PD-1 has been identified as a marker of exhausted T cells in chronic disea...

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Detalles Bibliográficos
Autores principales: Sakuishi, Kaori, Apetoh, Lionel, Sullivan, Jenna M., Blazar, Bruce R., Kuchroo, Vijay K., Anderson, Ana C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947065/
https://www.ncbi.nlm.nih.gov/pubmed/20819927
http://dx.doi.org/10.1084/jem.20100643

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