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IL-10 inhibits transcription elongation of the human TNF gene in primary macrophages
IL-10 plays a central nonredundant role in limiting inflammation in vivo. However, the mechanisms involved remain to be resolved. Using primary human macrophages, we found that IL-10 inhibits selected inflammatory genes, primarily at a level of transcription. At the TNF gene, this occurs not through...
Autores principales: | Smallie, Tim, Ricchetti, Giuseppe, Horwood, Nicole J., Feldmann, Marc, Clark, Andrew R., Williams, Lynn M. |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947066/ https://www.ncbi.nlm.nih.gov/pubmed/20805562 http://dx.doi.org/10.1084/jem.20100414 |
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