p53 connects tumorigenesis and reprogramming to pluripotency

The tumor suppressor gene p53 prevents the initiation of tumor formation by inducing cell cycle arrest, senescence, DNA repair, and apoptosis. Recently, the absence or mutation of p53 was described to facilitate nuclear reprogramming. These findings suggest an influence of p53 on the de-differentiat...

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Detalles Bibliográficos
Autores principales: Tapia, Natalia, Schöler, Hans R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947071/
https://www.ncbi.nlm.nih.gov/pubmed/20876313
http://dx.doi.org/10.1084/jem.20101866
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author Tapia, Natalia
Schöler, Hans R.
author_facet Tapia, Natalia
Schöler, Hans R.
author_sort Tapia, Natalia
collection PubMed
description The tumor suppressor gene p53 prevents the initiation of tumor formation by inducing cell cycle arrest, senescence, DNA repair, and apoptosis. Recently, the absence or mutation of p53 was described to facilitate nuclear reprogramming. These findings suggest an influence of p53 on the de-differentiation process, and highlight the similarities between induction of pluripotency and tumor formation.
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spelling pubmed-29470712011-03-27 p53 connects tumorigenesis and reprogramming to pluripotency Tapia, Natalia Schöler, Hans R. J Exp Med Minireview The tumor suppressor gene p53 prevents the initiation of tumor formation by inducing cell cycle arrest, senescence, DNA repair, and apoptosis. Recently, the absence or mutation of p53 was described to facilitate nuclear reprogramming. These findings suggest an influence of p53 on the de-differentiation process, and highlight the similarities between induction of pluripotency and tumor formation. The Rockefeller University Press 2010-09-27 /pmc/articles/PMC2947071/ /pubmed/20876313 http://dx.doi.org/10.1084/jem.20101866 Text en © 2010 Tapia and Scholer This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Minireview
Tapia, Natalia
Schöler, Hans R.
p53 connects tumorigenesis and reprogramming to pluripotency
title p53 connects tumorigenesis and reprogramming to pluripotency
title_full p53 connects tumorigenesis and reprogramming to pluripotency
title_fullStr p53 connects tumorigenesis and reprogramming to pluripotency
title_full_unstemmed p53 connects tumorigenesis and reprogramming to pluripotency
title_short p53 connects tumorigenesis and reprogramming to pluripotency
title_sort p53 connects tumorigenesis and reprogramming to pluripotency
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947071/
https://www.ncbi.nlm.nih.gov/pubmed/20876313
http://dx.doi.org/10.1084/jem.20101866
work_keys_str_mv AT tapianatalia p53connectstumorigenesisandreprogrammingtopluripotency
AT scholerhansr p53connectstumorigenesisandreprogrammingtopluripotency

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