Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain–dependent manner

Progressive accumulation of PrP(Sc), a hallmark of prion diseases, occurs when conversion of PrP(C) into PrP(Sc) is faster than PrP(Sc) clearance. Engulfment of apoptotic bodies by phagocytes is mediated by Mfge8 (milk fat globule epidermal growth factor 8). In this study, we show that brain Mfge8 i...

Descripción completa

Detalles Bibliográficos
Autores principales: Kranich, Jan, Krautler, Nike Julia, Falsig, Jeppe, Ballmer, Boris, Li, Shulei, Hutter, Gregor, Schwarz, Petra, Moos, Rita, Julius, Christian, Miele, Gino, Aguzzi, Adriano
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947076/
https://www.ncbi.nlm.nih.gov/pubmed/20837697
http://dx.doi.org/10.1084/jem.20092401

Ejemplares similares

Ejemplares similares