NKX3.1 is a direct TAL1 target gene that mediates proliferation of TAL1-expressing human T cell acute lymphoblastic leukemia

TAL1 (also known as SCL) is expressed in >40% of human T cell acute lymphoblastic leukemias (T-ALLs). TAL1 encodes a basic helix-loop-helix transcription factor that can interfere with the transcriptional activity of E2A and HEB during T cell leukemogenesis; however, the oncogenic pathways direct...

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Detalles Bibliográficos
Autores principales: Kusy, Sophie, Gerby, Bastien, Goardon, Nicolas, Gault, Nathalie, Ferri, Federica, Gérard, Delphine, Armstrong, Florence, Ballerini, Paola, Cayuela, Jean-Michel, Baruchel, André, Pflumio, Françoise, Roméo, Paul-Henri
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947082/
https://www.ncbi.nlm.nih.gov/pubmed/20855495
http://dx.doi.org/10.1084/jem.20100745

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