Reduced Expression of TCR Zeta Is Involved in the Abnormal Production of Cytokines by Peripheral T Cells of Patients with Systemic Lupus Erythematosus

Accumulating evidence suggests that dysfunction of T cells underlies the pathogenesis of systemic lupus erythematosus (SLE). We revealed that SLE T cells produced an abnormally excessive amount of IFN-γin vitro upon stimulation through TCR, and the expression level of TCR zeta was significantly redu...

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Detalles Bibliográficos
Autores principales: Yoshimoto, Keiko, Setoyama, Yumiko, Tsuzaka, Kensei, Abe, Tohru, Takeuchi, Tsutomu
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947188/
https://www.ncbi.nlm.nih.gov/pubmed/20936133
http://dx.doi.org/10.1155/2010/509021

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