Substrate-specific binding and conformational changes involving Ser(313) and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking

RFC (reduced folate carrier) is the major transporter for reduced folates and antifolates [e.g. MTX (methotrexate)]. RFC is characterized by two halves, each with six TMD (transmembrane domain) α helices connected by a hydrophilic loop, and cytoplasmic N- and C-termini. We previously identified TMDs...

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Detalles Bibliográficos
Autores principales: Hou, Zhanjun, Wu, Jianmei, Ye, Jun, Cherian, Christina, Matherly, Larry H.
Formato: Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947195/
https://www.ncbi.nlm.nih.gov/pubmed/20557288
http://dx.doi.org/10.1042/BJ20100181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947195/
https://www.ncbi.nlm.nih.gov/pubmed/20557288
http://dx.doi.org/10.1042/BJ20100181

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