FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells

Sphingosine kinase 1 (SK1) is an enzyme that catalyses the phosphorylation of sphingosine to produce the bioactive lipid sphingosine 1-phosphate (S1P). We demonstrate here that FTY720 (Fingolimod™) and (S)-FTY720 vinylphosphonate are novel inhibitors of SK1 catalytic activity and induce the proteaso...

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Detalles Bibliográficos
Autores principales: Tonelli, Francesca, Lim, Keng Gat, Loveridge, Carolyn, Long, Jaclyn, Pitson, Stuart M., Tigyi, Gabor, Bittman, Robert, Pyne, Susan, Pyne, Nigel J.
Formato: Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947314/
https://www.ncbi.nlm.nih.gov/pubmed/20570726
http://dx.doi.org/10.1016/j.cellsig.2010.05.022

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