A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma

We conducted a genome-wide association study of gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 single nucleotide polymorphisms (SNPs). We report a combined analysis of 2,240 GC cases, 2,115 ESCC cases, and 3,302 controls dra...

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Autores principales: Abnet, Christian C, Freedman, Neal D, Hu, Nan, Wang, Zhaoming, Yu, Kai, Shu, Xiao-Ou, Yuan, Jian-Min, Zheng, Wei, Dawsey, Sanford M, Dong, Linda M, Lee, Maxwell P, Ding, Ti, Qiao, You-Lin, Gao, Yu-Tang, Koh, Woon-Puay, Xiang, Yong-Bing, Tang, Ze-Zhong, Fan, Jin-Hu, Wang, Chaoyu, Wheeler, William, Gail, Mitchell H, Yeager, Meredith, Yuenger, Jeff, Hutchinson, Amy, Jacobs, Kevin B, Giffen, Carol A, Burdett, Laurie, Jr, Joseph F Fraumeni, Tucker, Margaret A, Chow, Wong-Ho, Goldstein, Alisa M, Chanock, Stephen J, Taylor, Philip R
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947317/
https://www.ncbi.nlm.nih.gov/pubmed/20729852
http://dx.doi.org/10.1038/ng.649
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author Abnet, Christian C
Freedman, Neal D
Hu, Nan
Wang, Zhaoming
Yu, Kai
Shu, Xiao-Ou
Yuan, Jian-Min
Zheng, Wei
Dawsey, Sanford M
Dong, Linda M
Lee, Maxwell P
Ding, Ti
Qiao, You-Lin
Gao, Yu-Tang
Koh, Woon-Puay
Xiang, Yong-Bing
Tang, Ze-Zhong
Fan, Jin-Hu
Wang, Chaoyu
Wheeler, William
Gail, Mitchell H
Yeager, Meredith
Yuenger, Jeff
Hutchinson, Amy
Jacobs, Kevin B
Giffen, Carol A
Burdett, Laurie
Jr, Joseph F Fraumeni
Tucker, Margaret A
Chow, Wong-Ho
Goldstein, Alisa M
Chanock, Stephen J
Taylor, Philip R
author_facet Abnet, Christian C
Freedman, Neal D
Hu, Nan
Wang, Zhaoming
Yu, Kai
Shu, Xiao-Ou
Yuan, Jian-Min
Zheng, Wei
Dawsey, Sanford M
Dong, Linda M
Lee, Maxwell P
Ding, Ti
Qiao, You-Lin
Gao, Yu-Tang
Koh, Woon-Puay
Xiang, Yong-Bing
Tang, Ze-Zhong
Fan, Jin-Hu
Wang, Chaoyu
Wheeler, William
Gail, Mitchell H
Yeager, Meredith
Yuenger, Jeff
Hutchinson, Amy
Jacobs, Kevin B
Giffen, Carol A
Burdett, Laurie
Jr, Joseph F Fraumeni
Tucker, Margaret A
Chow, Wong-Ho
Goldstein, Alisa M
Chanock, Stephen J
Taylor, Philip R
author_sort Abnet, Christian C
collection PubMed
description We conducted a genome-wide association study of gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 single nucleotide polymorphisms (SNPs). We report a combined analysis of 2,240 GC cases, 2,115 ESCC cases, and 3,302 controls drawn from five studies. In logistic regression models adjusted for age, sex, and study, multiple variants at 10q23 had genome-wide significance for GC and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for GC (P=8.40×10(−9); per allele odds ratio (OR) = 1.31) and ESCC (P=3.85×10(−9); OR = 1.34). The association with GC differed by anatomic subsite. For tumors located in the cardia the association was stronger (P=4.19 × 10(−15); OR= 1.57) and for those located in the noncardia stomach it was absent (P=0.44; OR=1.05). Our findings at 10q23 could provide insight into the high incidence rates of both cancers in China.
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spelling pubmed-29473172011-03-01 A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma Abnet, Christian C Freedman, Neal D Hu, Nan Wang, Zhaoming Yu, Kai Shu, Xiao-Ou Yuan, Jian-Min Zheng, Wei Dawsey, Sanford M Dong, Linda M Lee, Maxwell P Ding, Ti Qiao, You-Lin Gao, Yu-Tang Koh, Woon-Puay Xiang, Yong-Bing Tang, Ze-Zhong Fan, Jin-Hu Wang, Chaoyu Wheeler, William Gail, Mitchell H Yeager, Meredith Yuenger, Jeff Hutchinson, Amy Jacobs, Kevin B Giffen, Carol A Burdett, Laurie Jr, Joseph F Fraumeni Tucker, Margaret A Chow, Wong-Ho Goldstein, Alisa M Chanock, Stephen J Taylor, Philip R Nat Genet Article We conducted a genome-wide association study of gastric cancer (GC) and esophageal squamous cell carcinoma (ESCC) in ethnic Chinese subjects in which we genotyped 551,152 single nucleotide polymorphisms (SNPs). We report a combined analysis of 2,240 GC cases, 2,115 ESCC cases, and 3,302 controls drawn from five studies. In logistic regression models adjusted for age, sex, and study, multiple variants at 10q23 had genome-wide significance for GC and ESCC independently. A notable signal was rs2274223, a nonsynonymous SNP located in PLCE1, for GC (P=8.40×10(−9); per allele odds ratio (OR) = 1.31) and ESCC (P=3.85×10(−9); OR = 1.34). The association with GC differed by anatomic subsite. For tumors located in the cardia the association was stronger (P=4.19 × 10(−15); OR= 1.57) and for those located in the noncardia stomach it was absent (P=0.44; OR=1.05). Our findings at 10q23 could provide insight into the high incidence rates of both cancers in China. 2010-08-22 2010-09 /pmc/articles/PMC2947317/ /pubmed/20729852 http://dx.doi.org/10.1038/ng.649 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Abnet, Christian C
Freedman, Neal D
Hu, Nan
Wang, Zhaoming
Yu, Kai
Shu, Xiao-Ou
Yuan, Jian-Min
Zheng, Wei
Dawsey, Sanford M
Dong, Linda M
Lee, Maxwell P
Ding, Ti
Qiao, You-Lin
Gao, Yu-Tang
Koh, Woon-Puay
Xiang, Yong-Bing
Tang, Ze-Zhong
Fan, Jin-Hu
Wang, Chaoyu
Wheeler, William
Gail, Mitchell H
Yeager, Meredith
Yuenger, Jeff
Hutchinson, Amy
Jacobs, Kevin B
Giffen, Carol A
Burdett, Laurie
Jr, Joseph F Fraumeni
Tucker, Margaret A
Chow, Wong-Ho
Goldstein, Alisa M
Chanock, Stephen J
Taylor, Philip R
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
title A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
title_full A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
title_fullStr A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
title_full_unstemmed A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
title_short A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
title_sort shared susceptibility locus in plce1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947317/
https://www.ncbi.nlm.nih.gov/pubmed/20729852
http://dx.doi.org/10.1038/ng.649
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