Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line

Transcription, mRNA decay, translation and protein degradation are essential processes during eukaryotic gene expression, but their relative global contributions to steady-state protein concentrations in multi-cellular eukaryotes are largely unknown. Using measurements of absolute protein and mRNA a...

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Detalles Bibliográficos
Autores principales: Vogel, Christine, de Sousa Abreu, Raquel, Ko, Daijin, Le, Shu-Yun, Shapiro, Bruce A, Burns, Suzanne C, Sandhu, Devraj, Boutz, Daniel R, Marcotte, Edward M, Penalva, Luiz O
Formato: Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947365/
https://www.ncbi.nlm.nih.gov/pubmed/20739923
http://dx.doi.org/10.1038/msb.2010.59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947365/
https://www.ncbi.nlm.nih.gov/pubmed/20739923
http://dx.doi.org/10.1038/msb.2010.59

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