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The Double-stranded RNA–dependent Protein Kinase Differentially Regulates Insulin Receptor Substrates 1 and 2 in HepG2 Cells

Initially identified to be activated upon virus infection, the double-stranded RNA–dependent protein kinase (PKR) is best known for triggering cell defense responses by phosphorylating eIF-2α, thus suppressing RNA translation. We as well as others showed that the phosphorylation of PKR is down-regul...

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Detalles Bibliográficos
Autores principales:	Yang, Xuerui, Nath, Aritro, Opperman, Michael J., Chan, Christina
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2010
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947480/ https://www.ncbi.nlm.nih.gov/pubmed/20685959 http://dx.doi.org/10.1091/mbc.E10-06-0481

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