The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo

The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention. We use genetic reporters to demonstrate activation of...

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Detalles Bibliográficos
Autores principales: Loewen, Carin A., Feany, Mel B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947516/
https://www.ncbi.nlm.nih.gov/pubmed/20927324
http://dx.doi.org/10.1371/journal.pone.0013084
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author Loewen, Carin A.
Feany, Mel B.
author_facet Loewen, Carin A.
Feany, Mel B.
author_sort Loewen, Carin A.
collection PubMed
description The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention. We use genetic reporters to demonstrate activation of the unfolded protein response in a transgenic Drosophila model of Alzheimer's disease and related tauopathies. We then use loss of function genetic reagents to support a role for the unfolded protein response in protecting from tau neurotoxicity. Our findings suggest that the unfolded protein response can ameliorate the toxicity of tau in vivo.
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spelling pubmed-29475162010-10-06 The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo Loewen, Carin A. Feany, Mel B. PLoS One Research Article The unfolded protein response is a critical system by which the cell handles excess misfolded protein in the secretory pathway. The role of the system in modulating the effects of aggregation prone cytosolic proteins has received less attention. We use genetic reporters to demonstrate activation of the unfolded protein response in a transgenic Drosophila model of Alzheimer's disease and related tauopathies. We then use loss of function genetic reagents to support a role for the unfolded protein response in protecting from tau neurotoxicity. Our findings suggest that the unfolded protein response can ameliorate the toxicity of tau in vivo. Public Library of Science 2010-09-29 /pmc/articles/PMC2947516/ /pubmed/20927324 http://dx.doi.org/10.1371/journal.pone.0013084 Text en Loewen, Feany. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Loewen, Carin A.
Feany, Mel B.
The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo
title The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo
title_full The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo
title_fullStr The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo
title_full_unstemmed The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo
title_short The Unfolded Protein Response Protects from Tau Neurotoxicity In Vivo
title_sort unfolded protein response protects from tau neurotoxicity in vivo
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947516/
https://www.ncbi.nlm.nih.gov/pubmed/20927324
http://dx.doi.org/10.1371/journal.pone.0013084
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