Mechanical Stress Activates Smad Pathway through PKCδ to Enhance Interleukin-11 Gene Transcription in Osteoblasts

BACKGROUND: Mechanical stress rapidly induces ΔFosB expression in osteoblasts, which binds to interleukin (IL)-11 gene promoter to enhance IL-11 expression, and IL-11 enhances osteoblast differentiation. Because bone morphogenetic proteins (BMPs) also stimulate IL-11 expression in osteoblasts, there...

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Detalles Bibliográficos
Autores principales: Kido, Shinsuke, Kuriwaka-Kido, Rika, Umino-Miyatani, Yuka, Endo, Itsuro, Inoue, Daisuke, Taniguchi, Hisaaki, Inoue, Yasumichi, Imamura, Takeshi, Matsumoto, Toshio
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947522/
https://www.ncbi.nlm.nih.gov/pubmed/20927330
http://dx.doi.org/10.1371/journal.pone.0013090

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