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Cholestatic Jaundice Induced by Duloxetine in a Patient with Major Depressive Disorder

Duloxetine is a balanced and potent serotonin and noradrenaline reuptake inhibitor (SNRI) and has adverse effects that are commonly associated with such drugs, including nausea, dry mouth, constipation, insomnia, and dizziness. Recently, duloxetine-induced liver injury has also been observed in pati...

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Autores principales: Park, Young-Min, Lee, Bun-Hee, Lee, Heon-Jeong, Kang, Seung-Gul
Formato: Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947813/
https://www.ncbi.nlm.nih.gov/pubmed/20927314
http://dx.doi.org/10.4306/pi.2010.7.3.228
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author Park, Young-Min
Lee, Bun-Hee
Lee, Heon-Jeong
Kang, Seung-Gul
author_facet Park, Young-Min
Lee, Bun-Hee
Lee, Heon-Jeong
Kang, Seung-Gul
author_sort Park, Young-Min
collection PubMed
description Duloxetine is a balanced and potent serotonin and noradrenaline reuptake inhibitor (SNRI) and has adverse effects that are commonly associated with such drugs, including nausea, dry mouth, constipation, insomnia, and dizziness. Recently, duloxetine-induced liver injury has also been observed in patients with preexisting liver disease or chronic alcohol use. We investigated the effects of duloxetine in a healthy young adult with major depressive disorder (MDD) but no risk factors, and found that his total bilirubin level increased to 3.3 mg/dL and he developed jaundice after 5 months of duloxetine treatment. Discontinuation of duloxetine treatment saw his total bilirubin level decrease to 1.8 mg/dL. Thus, the administration of duloxetine might induce liver injury in a patient with MDD. However, the limitations of this single case report must be acknowledged. Although the cause of hepatic dysfunction in this case remains to be elucidated, clinicians should monitor liver function carefully after duloxetine treatment. Further investigations with a larger sample are needed.
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spelling pubmed-29478132010-10-06 Cholestatic Jaundice Induced by Duloxetine in a Patient with Major Depressive Disorder Park, Young-Min Lee, Bun-Hee Lee, Heon-Jeong Kang, Seung-Gul Psychiatry Investig Case Report Duloxetine is a balanced and potent serotonin and noradrenaline reuptake inhibitor (SNRI) and has adverse effects that are commonly associated with such drugs, including nausea, dry mouth, constipation, insomnia, and dizziness. Recently, duloxetine-induced liver injury has also been observed in patients with preexisting liver disease or chronic alcohol use. We investigated the effects of duloxetine in a healthy young adult with major depressive disorder (MDD) but no risk factors, and found that his total bilirubin level increased to 3.3 mg/dL and he developed jaundice after 5 months of duloxetine treatment. Discontinuation of duloxetine treatment saw his total bilirubin level decrease to 1.8 mg/dL. Thus, the administration of duloxetine might induce liver injury in a patient with MDD. However, the limitations of this single case report must be acknowledged. Although the cause of hepatic dysfunction in this case remains to be elucidated, clinicians should monitor liver function carefully after duloxetine treatment. Further investigations with a larger sample are needed. Korean Neuropsychiatric Association 2010-09 2010-08-30 /pmc/articles/PMC2947813/ /pubmed/20927314 http://dx.doi.org/10.4306/pi.2010.7.3.228 Text en Copyright © 2010 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Park, Young-Min
Lee, Bun-Hee
Lee, Heon-Jeong
Kang, Seung-Gul
Cholestatic Jaundice Induced by Duloxetine in a Patient with Major Depressive Disorder
title Cholestatic Jaundice Induced by Duloxetine in a Patient with Major Depressive Disorder
title_full Cholestatic Jaundice Induced by Duloxetine in a Patient with Major Depressive Disorder
title_fullStr Cholestatic Jaundice Induced by Duloxetine in a Patient with Major Depressive Disorder
title_full_unstemmed Cholestatic Jaundice Induced by Duloxetine in a Patient with Major Depressive Disorder
title_short Cholestatic Jaundice Induced by Duloxetine in a Patient with Major Depressive Disorder
title_sort cholestatic jaundice induced by duloxetine in a patient with major depressive disorder
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947813/
https://www.ncbi.nlm.nih.gov/pubmed/20927314
http://dx.doi.org/10.4306/pi.2010.7.3.228
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