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HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse
The virological synapse (VS) is a tight adhesive junction between an HIV-infected cell and an uninfected target cell, across which virus can be efficiently transferred from cell to cell in the absence of cell-cell fusion. The VS has been postulated to resemble, in its morphology, the well-studied im...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Molecular Diversity Preservation International (MDPI)
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947835/ https://www.ncbi.nlm.nih.gov/pubmed/20890395 http://dx.doi.org/10.3390/v2051239 |
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author | Vasiliver-Shamis, Gaia Dustin, Michael L. Hioe, Catarina E. |
author_facet | Vasiliver-Shamis, Gaia Dustin, Michael L. Hioe, Catarina E. |
author_sort | Vasiliver-Shamis, Gaia |
collection | PubMed |
description | The virological synapse (VS) is a tight adhesive junction between an HIV-infected cell and an uninfected target cell, across which virus can be efficiently transferred from cell to cell in the absence of cell-cell fusion. The VS has been postulated to resemble, in its morphology, the well-studied immunological synapse (IS). This review article discusses the structural similarities between IS and VS and the shared T cell receptor (TCR) signaling components that are found in the VS. However, the IS and the VS display distinct kinetics in disassembly and intracellular signaling events, possibly leading to different biological outcomes. Hence, HIV-1 exploits molecular components of IS and TCR signaling machinery to trigger unique changes in cellular morphology, migration, and activation that facilitate its transmission and cell-to-cell spread. |
format | Text |
id | pubmed-2947835 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-29478352010-09-30 HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse Vasiliver-Shamis, Gaia Dustin, Michael L. Hioe, Catarina E. Viruses Review The virological synapse (VS) is a tight adhesive junction between an HIV-infected cell and an uninfected target cell, across which virus can be efficiently transferred from cell to cell in the absence of cell-cell fusion. The VS has been postulated to resemble, in its morphology, the well-studied immunological synapse (IS). This review article discusses the structural similarities between IS and VS and the shared T cell receptor (TCR) signaling components that are found in the VS. However, the IS and the VS display distinct kinetics in disassembly and intracellular signaling events, possibly leading to different biological outcomes. Hence, HIV-1 exploits molecular components of IS and TCR signaling machinery to trigger unique changes in cellular morphology, migration, and activation that facilitate its transmission and cell-to-cell spread. Molecular Diversity Preservation International (MDPI) 2010-05-21 /pmc/articles/PMC2947835/ /pubmed/20890395 http://dx.doi.org/10.3390/v2051239 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Vasiliver-Shamis, Gaia Dustin, Michael L. Hioe, Catarina E. HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse |
title | HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse |
title_full | HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse |
title_fullStr | HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse |
title_full_unstemmed | HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse |
title_short | HIV-1 Virological Synapse is not Simply a Copycat of the Immunological Synapse |
title_sort | hiv-1 virological synapse is not simply a copycat of the immunological synapse |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947835/ https://www.ncbi.nlm.nih.gov/pubmed/20890395 http://dx.doi.org/10.3390/v2051239 |
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