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Palatable Meal Anticipation in Mice
The ability to sense time and anticipate events is a critical skill in nature. Most efforts to understand the neural and molecular mechanisms of anticipatory behavior in rodents rely on daily restricted food access, which induces a robust increase of locomotor activity in anticipation of daily meal...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Public Library of Science
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948008/ https://www.ncbi.nlm.nih.gov/pubmed/20941366 http://dx.doi.org/10.1371/journal.pone.0012903 |
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author | Hsu, Cynthia T. Patton, Danica F. Mistlberger, Ralph E. Steele, Andrew D. |
author_facet | Hsu, Cynthia T. Patton, Danica F. Mistlberger, Ralph E. Steele, Andrew D. |
author_sort | Hsu, Cynthia T. |
collection | PubMed |
description | The ability to sense time and anticipate events is a critical skill in nature. Most efforts to understand the neural and molecular mechanisms of anticipatory behavior in rodents rely on daily restricted food access, which induces a robust increase of locomotor activity in anticipation of daily meal time. Interestingly, rats also show increased activity in anticipation of a daily palatable meal even when they have an ample food supply, suggesting a role for brain reward systems in anticipatory behavior, and providing an alternate model by which to study the neurobiology of anticipation in species, such as mice, that are less well adapted to “stuff and starve” feeding schedules. To extend this model to mice, and exploit molecular genetic resources available for that species, we tested the ability of wild-type mice to anticipate a daily palatable meal. We observed that mice with free access to regular chow and limited access to highly palatable snacks of chocolate or “Fruit Crunchies” avidly consumed the snack but did not show anticipatory locomotor activity as measured by running wheels or video-based behavioral analysis. However, male mice receiving a snack of high fat chow did show increased food bin entry prior to access time and a modest increase in activity in the two hours preceding the scheduled meal. Interestingly, female mice did not show anticipation of a daily high fat meal but did show increased activity at scheduled mealtime when that meal was withdrawn. These results indicate that anticipation of a scheduled food reward in mice is behavior, diet, and gender specific. |
format | Text |
id | pubmed-2948008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-29480082010-10-12 Palatable Meal Anticipation in Mice Hsu, Cynthia T. Patton, Danica F. Mistlberger, Ralph E. Steele, Andrew D. PLoS One Research Article The ability to sense time and anticipate events is a critical skill in nature. Most efforts to understand the neural and molecular mechanisms of anticipatory behavior in rodents rely on daily restricted food access, which induces a robust increase of locomotor activity in anticipation of daily meal time. Interestingly, rats also show increased activity in anticipation of a daily palatable meal even when they have an ample food supply, suggesting a role for brain reward systems in anticipatory behavior, and providing an alternate model by which to study the neurobiology of anticipation in species, such as mice, that are less well adapted to “stuff and starve” feeding schedules. To extend this model to mice, and exploit molecular genetic resources available for that species, we tested the ability of wild-type mice to anticipate a daily palatable meal. We observed that mice with free access to regular chow and limited access to highly palatable snacks of chocolate or “Fruit Crunchies” avidly consumed the snack but did not show anticipatory locomotor activity as measured by running wheels or video-based behavioral analysis. However, male mice receiving a snack of high fat chow did show increased food bin entry prior to access time and a modest increase in activity in the two hours preceding the scheduled meal. Interestingly, female mice did not show anticipation of a daily high fat meal but did show increased activity at scheduled mealtime when that meal was withdrawn. These results indicate that anticipation of a scheduled food reward in mice is behavior, diet, and gender specific. Public Library of Science 2010-09-30 /pmc/articles/PMC2948008/ /pubmed/20941366 http://dx.doi.org/10.1371/journal.pone.0012903 Text en Hsu et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Hsu, Cynthia T. Patton, Danica F. Mistlberger, Ralph E. Steele, Andrew D. Palatable Meal Anticipation in Mice |
title | Palatable Meal Anticipation in Mice |
title_full | Palatable Meal Anticipation in Mice |
title_fullStr | Palatable Meal Anticipation in Mice |
title_full_unstemmed | Palatable Meal Anticipation in Mice |
title_short | Palatable Meal Anticipation in Mice |
title_sort | palatable meal anticipation in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948008/ https://www.ncbi.nlm.nih.gov/pubmed/20941366 http://dx.doi.org/10.1371/journal.pone.0012903 |
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