Crystal Structure of the Formin mDia1 in Autoinhibited Conformation

BACKGROUND: Formin proteins utilize a conserved formin homology 2 (FH2) domain to nucleate new actin filaments. In mammalian diaphanous-related formins (DRFs) the FH2 domain is inhibited through an unknown mechanism by intramolecular binding of the diaphanous autoinhibitory domain (DAD) and the diap...

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Detalles Bibliográficos
Autores principales: Otomo, Takanori, Tomchick, Diana R., Otomo, Chinatsu, Machius, Mischa, Rosen, Michael K.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948019/
https://www.ncbi.nlm.nih.gov/pubmed/20927343
http://dx.doi.org/10.1371/journal.pone.0012896

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948019/
https://www.ncbi.nlm.nih.gov/pubmed/20927343
http://dx.doi.org/10.1371/journal.pone.0012896

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