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Crystal Structure of the Formin mDia1 in Autoinhibited Conformation

BACKGROUND: Formin proteins utilize a conserved formin homology 2 (FH2) domain to nucleate new actin filaments. In mammalian diaphanous-related formins (DRFs) the FH2 domain is inhibited through an unknown mechanism by intramolecular binding of the diaphanous autoinhibitory domain (DAD) and the diap...

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Detalles Bibliográficos
Autores principales:	Otomo, Takanori, Tomchick, Diana R., Otomo, Chinatsu, Machius, Mischa, Rosen, Michael K.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948019/ https://www.ncbi.nlm.nih.gov/pubmed/20927343 http://dx.doi.org/10.1371/journal.pone.0012896

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