SH2 Modified STAT1 Induces HLA-I Expression and Improves IFN-γ Signaling in IFN-α Resistant HCV Replicon Cells

BACKGROUND: We have developed multiple stable cell lines containing subgenomic HCV RNA that are resistant to treatment with interferon alpha (IFN-α. Characterization of these IFN-α resistant replicon cells showed defects in the phosphorylation and nuclear translocation of STAT1 and STAT2 proteins du...

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Detalles Bibliográficos
Autores principales: Poat, Bret, Hazari, Sidhartha, Chandra, Partha K., Gunduz, Feyza, Balart, Luis A., Alvarez, Xavier, Dash, Srikanta
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948020/
https://www.ncbi.nlm.nih.gov/pubmed/20949125
http://dx.doi.org/10.1371/journal.pone.0013117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948020/
https://www.ncbi.nlm.nih.gov/pubmed/20949125
http://dx.doi.org/10.1371/journal.pone.0013117

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